Nephrology Book

http://www.fpnotebook.com/

Patiromer

Aka: Patiromer, Veltassa
  1. Indications
    1. Hyperkalemia
  2. Contraindications
    1. Bowel Obstruction
    2. Fecal Impaction
    3. Severe Constipation
  3. Mechanism
    1. Potassium binding agent
    2. Exchanges calcium for free Potassium in the gastrointestinal tract
    3. Results in greater Potassium excretion in the stool, and hence lower Serum Potassium levels
  4. Precautions
    1. Delayed onset of action
      1. Use other rapid acting measures to lower Potassium in life-threatening Hyperkalemia
    2. Electrolyte loss
      1. Monitor Potassium and Magnesium levels
      2. Magnesium Supplementation as needed
  5. Dosing
    1. Start: 8.4 g once daily
    2. Next: Increase to16.8 g once daily after at least one week if needed
    3. Next: Increase to 25.2 g once daily (max dose) after at least one week at 16.8 g dose
  6. Adverse Effects
    1. Electrolytes
      1. Hypomagnesemia (5-9%)
      2. Hypokalemia (5%)
    2. Gastrointestinal (increased Incidence in elderly patients)
      1. Transient Constipation (7%)
      2. Diarrhea (5%)
      3. Nausea (2%)
      4. Abdominal Pain (2%)
      5. Flatulence (2%)
    3. Hypersensitivity
      1. Lip edema (<1%)
  7. References
    1. Lovecchio (2017) Crit Dec Emerg Med 31(2): 24
    2. Chaitman (2016) P T 41(1): 43-50+PMID:26765867 [PubMed]

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree