Nephrology Book

Medication Causes of Edema

Aka: Medication Causes of Edema, Edema Secondary to Medications
  1. Causes: Typically due to salt and water retention unless otherwise noted
    1. Antihypertensives
      1. Hydralazine
      2. Diazoxide (Hyperstat)
      3. Minoxidil
      4. Methyldopa
      5. Calcium Channel Blockers (e.g. Amlodipine)
      6. Beta Blockers
      7. Clonidine (Catapres)
    2. Nonsteroidal Antiinflammatory Drugs (NSAIDs)
      1. Ibuprofen
      2. Celecoxib (Celebrex)
    3. Endocrine agents
      1. Corticosteroids
      2. Estrogen
      3. Progesterone
      4. Testosterone
      5. Insulin
      6. Thiazolidinedione (e.g. Actos, Avandia)
    4. Antidepressants
      1. Monoamine Oxidase Inhibitors
      2. Trazodone
    5. Chemotherapy
      1. Interleukin-2 (Increased Vascular permeability)
      2. Interleukin-4
      3. Interferon alfa
      4. Docetaxel (Taxotere)
      5. Cyclophosphamide
      6. Cyclosporine
      7. Mithramycin
      8. Cytosine Arbinoside
      9. Granulocyte colony-stmulating factor
      10. Granulocyte-Macrophage colony stimulating factor
    6. Antipsychotics: Phenothiazines
      1. Thioridazine (Mellaril)
      2. Chlorpromazine (Thorazine)
      3. Trifluoperazine (Stelazine)
      4. Thiothixene (Navane)
    7. Diuretic Abuse or Laxative abuse
      1. Increases renin and aldosterone levels
      2. Rebound salt retention on stopping medication
    8. Miscellaneous agents
      1. Acyclovir (Zovirax)
      2. Pramipexole (Mirapex)
  2. References
    1. Trayes (2013) Am Fam Physician 88(2): 102-10 [PubMed]

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