Nephrology Book

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Minimal Change Disease

Aka: Minimal Change Disease, NIL Lesion, Lipoid nephrosis
  1. See Also
    1. Nephrotic Syndrome
  2. Epidemiology
    1. Most common cause of Nephrotic Syndrome in children
    2. Common cause of idiopathic Nephrotic Syndrome
  3. Causes
    1. Idiopathic in most cases
    2. May follow Upper Respiratory Infection or Immunization
  4. Labs: Pathology
    1. Effacement of foot processes on electron microscopy
    2. Glomeruli appear normal on renal biopsy
  5. Signs
    1. See Nephrotic Syndrome
  6. References
    1. Karnath (2007) Hosp Physician 43(10): 25-30 [PubMed]
    2. Kodner (2009) Am Fam Physician 80(10): 1129-36 [PubMed]

Lipoid nephrosis (C0027721)

Definition (MSHCZE) Onemocnění ledvin vyskytující se obv. u dětí, charakterizované nefrotickým syndromem s velkými ztrátami bílkovin močí. Podstatou jsou změny glomerulu (glomerulopatie), které jsou patrny jen elektronovým mikroskopem (nověji se užívá termínu „minimal changes disease"). V léčbě jsou účinné kortikoidy. (cit. Velký lékařský slovník online, 2012 http://lekarske.slovniky.cz/ )
Definition (MSH) A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.
Concepts Disease or Syndrome (T047)
MSH D009402
ICD10 N04
SnomedCT 197592009, 44785005
English Minimal change nephrotic syndrome, Lipoid Nephroses, Lipoid Nephrosis, Minimal Change Nephropathies, Nephropathies, Minimal Change, Nephropathy, Minimal Change, Nephroses, Lipoid, Nephrosis, Lipoid, Minimal Change Nephropathy, Idiopathic nephrotic syndrome, Light negative GN, MCN - Minimal change nephrop, Minimal change nephrotic synd, Glomerulopathies, Minimal Change, Glomerulopathy, Minimal Change, Minimal Change Glomerulopathy, lipoid nephrosis, Nephrosis, Lipoid [Disease/Finding], change diseases minimal, nephrosis lipoid, change glomerulonephritis minimal, change disease minimal, changes glomerulonephritis minimal, minimal change nephropathy, nil disease, minimal change disease, disease nils, Diseases, Minimal Change, Minimal Change Disease, Idiopathic Minimal Change Nephrotic Syndrome, Disease, Minimal Change, Minimal Change Diseases, Change Diseases, Minimal, Minimal change nephropathy, Lipid nephrosis, Minimal change disease, Nil disease, Light negative glomerulonephritis, MCD - Minimal change disease, MCN - Minimal change nephropathy, Minimal change disease (disorder), lipoid; nephrosis, nephrosis; lipoid, Lipoid nephrosis, Foot process disease
Dutch minimale verandering in ziekte, lipoïdenefrose, lipoïd; nefrose, nefrose; lipoïd, Glomerulopathy, minimal-change, Nefrotisch syndroom, 'minimal-change', Nephropathy, minimal-change, Lipoïde nefrose, Nefrose, lipoïde
French Maladie à changement minime, Néphrose lipoïdique, Néphropathie à lésion glomérulaire minime, Syndrome néphrotique pur, Syndrome néphrotique à lésions glomérulaires minimes
German Minimal-changes-GP, Minimal Change Glomerulopathie, Minimal Change Nephrose, Lipoid-Nephrose, Minimal-Change-Glomerulopathie, Minimal-Change-Nephrose, Nephrose, Lipoid-, Lipoidnephrose
Italian Malattia a lesioni minime, Nefrosi lipoidea, Nefrosi lipoide
Portuguese Doença de alteração mínima, Nefrose lipóide, Glomerulopatia de Lesões Mínimas, Nefrose Lipoide, Nefropatia de Lesões Mínimas
Spanish Nefrosis lipoide, Enfermedad de cambios mínimos, Nefropatía de Cambios Mínimos, Glomerulopatía de Cambios Mínimos, Síndrome Nefrótico de Lesión Mínima, Síndrome Nefrótico de Variación Mínima, Glomerulonefritis de Lesiones Mínimas, Glomerulopatía de Lesiones Mínimas, Síndrome Nefrótico de Lesiones Mínimas, enfermedad de Nil, enfermedad de cambios mínimos, glomerulopatía con cambios mínimos (trastorno), glomerulopatía con cambios mínimos, nefrosis lipoidea, Nefrosis Lipoidea
Japanese 微小変化群, リポイドネフローゼ, ビショウヘンカグン, 糸球体腎炎-微少変化, ネフローゼ-リポイド, リポイドネフローゼ, リポイド変性ネフローゼ, 微小変化ネフローゼ症候群, 微小変化糸球体腎炎, 微小変化腎症, 類脂質変性ネフローゼ, ネフローゼ-リポイド変性, ネフローゼ-類脂質変性, ネフローゼ症候群-微小変化型, ネフローゼ症候群-微少変化, 微小変化型ネフローゼ症候群, 微少変化ネフローゼ症候群, 微少変化型ネフローゼ症候群, 微少変化型糸球体腎炎, 微少変化型腎症, 微少変化糸球体腎炎, 微少変化腎症, 腎症-微少変化, 類脂ネフローゼ, 類脂変性ネフローゼ, 類脂質ネフローゼ
Swedish Lipoidnefros
Finnish Lipoidinefroosi
Russian NEFROPATIIA, MINIMAL'NYE IZMENENIIA, NEFROZ LIPOIDNYI, GLOMERULONEFRIT, MINIMAL'NYE IZMENENIIA, NEFROTICHESKII SINDROM, MINIMAL'NYE IZMENENIIA, ГЛОМЕРУЛОНЕФРИТ, МИНИМАЛЬНЫЕ ИЗМЕНЕНИЯ, НЕФРОЗ ЛИПОИДНЫЙ, НЕФРОПАТИЯ, МИНИМАЛЬНЫЕ ИЗМЕНЕНИЯ, НЕФРОТИЧЕСКИЙ СИНДРОМ, МИНИМАЛЬНЫЕ ИЗМЕНЕНИЯ
Czech Lipoidní nefróza, Glomerulonefritida s minimálními změnami, nefróza lipoidní, nemoc minimálních změn, glomerulopatie s minimálními změnami, idiopatický nefrotický syndrom s minimálními změnami, lipoidní nefróza
Polish Nerczyca lipidowa
Hungarian Lipoid nephrosis, Minimal-change betegség
Croatian NEFROZA, LIPOIDNA
Norwegian Lipoid nefrose
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nephrotic Syndrome, Minimal Change (C1704321)

Definition (NCI) A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the glomerular capillaries and the effacement of the surrounding epithelial cell foot processes worsening protein leakage. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.
Concepts Disease or Syndrome (T047)
MSH D009402
ICD9 581.3
SnomedCT 44785005
English Nephrotic syndrome with lesion of minimal change glomerulonephritis, MCNS-Minimal change neph synd, Nephrotic Syndrome, Minimal Change, Minimal change nephrosis, idiopathic nephrotic syndrome, Minimal Change Nephrotic Syndrome, Minimal change nephrotic syndrome, Idiopathic nephrotic syndrome, MCNS - Minimal change nephrotic syndrome, Nephrotic Syndrome with Lesion of Minimal Change Glomerulonephritis, Nephrotic syndrome with lesion of minimal change glomerular disease, Nephrotic syndrome with lesion of minimal change glomerulitis, Nephrotic syndrome with lesion of minimal change nephrotic syndrome
Dutch nefrotisch syndroom met minimale letsels
French Syndrome néphrotique avec lésion de glomérulonéphrite à changement minime
German nephrotisches Syndrom mit Laesion minimal veraenderlicher Glomerulonephritis, Glomeruläre Minimalveränderung, MCNS, Minimal-Change NS, Minimal-Change-Nephrotic-Syndrom
Italian Sindrome nefrosica, con lesione di tipo glomerulonefrite a variazione minima, Sindrome nefrosica minimo cambiamento
Portuguese Síndrome nefrótica com lesão de glomerulonefrite de alteração mínima, Síndrome Nefrótica de Lesões Mínimas
Spanish Síndrome nefrótico con lesión de gomerulonefritis con cambios mínimos, Síndrome Nefrótico de Cambios Mínimos
Japanese 微少病変糸球体腎炎を伴うネフローゼ症候群, ビショウビョウヘンシキュウタイジンエンヲトモナウネフローゼショウコウグン
Czech Nefrotický syndrom na podkladě minimálních glomerulárních změn, nefrotický syndrom s minimálními změnami
Hungarian Nephrosis syndroma minimal-change glomerulonephritis laesióval
Norwegian Minimal change nefrotisk syndrom
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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