Nephrology Book

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Acute Glomerulonephritis

Aka: Acute Glomerulonephritis, Glomerulonephritis
  1. See Also
    1. Acute Kidney Injury
    2. Glomerulonephritis Causes
  2. Definition
    1. Gross Hematuria with Red Blood Cell casts
    2. Proteinuria
    3. Hypertension
    4. Renal Insufficiency
  3. Causes
    1. See Glomerulonephritis Causes
    2. Nephrotic Syndrome
      1. Minimal Change Disease (NIL Lesion, Lipoid nephrosis)
      2. Focal Segmental Glomerulosclerosis
      3. Membranous Glomerulonephritis
      4. Paraproteinemia (Multiple Myeloma)
    3. Nephritis with low complement
      1. Postinfectious proliferative Glomerulonephritis
        1. Poststreptococcal Glomerulonephritis (classic)
        2. Subacute Bacterial Endocarditis
        3. Osteomyelitis
      2. Membranoproliferative Glomerulonephritis
      3. Systemic Lupus Erythematosus
      4. Cryoglobulinemia
      5. Diabetes Mellitus
      6. Hepatitis CVirus
    4. Nephritis with normal complement
      1. IgA Nephropathy (Berger's Disease)
      2. Fibrillary Glomerulonephritis
      3. Goodpasture's Syndrome
      4. Rapidly Progressive Glomerulonephritis
      5. Renal Vasculitis
      6. Wegner's Granulomatosis
      7. Polyarteritis Nodosa
  4. Symptoms (variably present)
    1. Malaise
    2. Headache
    3. Anorexia
    4. Low grade fever
  5. Symptoms and Signs
    1. Edema
    2. Hypertension
  6. Labs: Initial (characterize condition)
    1. Urine sediment examination
      1. Proteinuria
      2. Glomerular Hematuria
        1. Pigmented or Red Blood Cell casts
        2. Dysmorphic Red Blood Cells
    2. Twenty-four hour urine collection
      1. 24 Hour Urine Protein
      2. Creatine Clearance
        1. Renal Insufficiency
    3. Routine blood testing
      1. Serum chemistries (e.g. Chem8)
      2. Albumin and Liver Function Tests
      3. Total Cholesterol
    4. If over age 40 with Proteinuria >1 gram/24 hours
      1. Serum Protein Electrophoresis (SPEP)
      2. Urine Protein electrophoresis
  7. Labs: Next (Screen for etiology)
    1. Serum Complement (C3, C4, CH50)
    2. Antinuclear Antibody (ANA)
    3. Rheumatoid Factor (RF)
    4. Erythrocyte Sedimentation Rate (ESR)
    5. Anti-Glomerular Basement Membrane Antibody titer
    6. Hepatitis serology (HBsAg, xHBc IgM, HCV)
    7. Anti-Neutrophilic cytoplasmic Antibody (ANCA)
    8. Anti-streptolysin O titer (ASO Titer)
    9. Human Immunodeficiency Virus (HIV)
  8. Diagnostics
    1. Renal Ultrasound
    2. Renal biopsy
  9. Management
    1. Treat specific cause

Glomerulonephritis (C0017658)

Definition (NCI) A renal disorder characterized by damage in the glomeruli. It may be acute or chronic, focal or diffuse, and it may lead to renal failure. Causes include autoimmune disorders, infections, diabetes, and malignancies.
Definition (CSP) glomerular disease characterized by an inflammatory reaction, with leukocyte infiltration and cellular proliferation of the glomeruli, or that appears to be the result of immune glomerular injury.
Definition (MSH) Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Concepts Disease or Syndrome (T047)
MSH D005921
ICD10 N05, N08
SnomedCT 197648001, 36171008
English Glomerulonephritides, GLOMERULONEPHRITIS, Glomerulonephritis unspec.NOS, Glomerulonephritis, Unspecified glomerulonephritis NOS, glomerulonephritis (diagnosis), glomerulonephritis, Nephritis-glomerular, Glomerulonephritis NOS, glomerulonephritis NOS, Glomerulonephritis [Disease/Finding], glomerulonephritides, Unspecified glomerulonephritis NOS (disorder), GN - Glomerulonephritis, Glomerulonephritis (disorder), Glomerulonephritis, NOS
French GLOMERULONEPHRITE, Néphrite glomérulaire, Glomérulonéphrite SAI, Glomérulonéphrite, Néphropathie glomérulaire
Portuguese GLOMERULONEFRITE, Glomerulonefrite NE, Nefrite glomerular, Glomerulonefrite
Spanish GLOMERULONEFRITIS, Glomerulonefritis NEOM, Nefritis glomerular, glomerulonefritis no especificada, SAI (trastorno), glomerulonefritis no especificada, SAI, glomerulonefritis (trastorno), glomerulonefritis, Glomerulonefritis
German GLOMERULONEPHRITIS, Nephritis, glomerulaer, Glomerulonephritis NNB, Glomerulonephritis
Dutch glomerulonefritis NAO, nefritis-glomerulair, glomerulonefritis, Bright-ziekte, Glomerulonefritis, Heymann-nefritis
Italian Glomerulonefrite NAS, Glomerulonefrite
Japanese 糸球体腎炎, 糸球体腎炎NOS, シキュウタイジンエンNOS, シキュウタイジンエン
Swedish Glomerulonefrit
Czech glomerulonefritida, Glomerulonefritida NOS, Glomerulonefritida
Finnish Munuaiskerästulehdus
Russian GLOMERULONEFRIT, NEFRIT KHEIMANA, GLOMERULONEFRIT PODOSTRYI, BRAITOVA BOLEZN', GLOMERULONEFRIT BRAITA, БРАЙТОВА БОЛЕЗНЬ, ГЛОМЕРУЛОНЕФРИТ, ГЛОМЕРУЛОНЕФРИТ БРАЙТА, ГЛОМЕРУЛОНЕФРИТ ПОДОСТРЫЙ, НЕФРИТ ХЕЙМАНА
Croatian GLOMERULONEFRITIS
Polish Zapalenie nerek kłębuszkowe, Kłębuszkowe zapalenie nerek, Glomerulopatia
Hungarian Glomerularis nephritis, glomerulonephritis, glomerulonephritis k.m.n.
Norwegian Glomerulonefritt
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Acute glomerulonephritis (C0156221)

Concepts Disease or Syndrome (T047)
ICD9 580
ICD10 N00
SnomedCT 155850003, 266613008, 197588002, 197578003, 19351000
English GLOMERULONEPHRITIS ACUTE, Acute glomerulonephritis NOS, acute glomerulonephritis (diagnosis), acute glomerulonephritis, Glomerulonephritis acute, Glomerulonephritis;acute, glomerulonephritis acute, Glomeruloneph.- acute, Acute glomerulonephritis NOS (disorder), Acute glomerulonephritis, AGN - Acute glomerulonephritis, Acute exudative glomerulonephritis, Acute glomerulonephritis (disorder), glomerulonephritis; acute, acute; glomerulonephritis, Acute glomerulonephritis, NOS, Acute Glomerulonephritis, Glomerulonephritis NOS, specified as acute
Italian Glomerulonefrite acuta
German akute Glomerulonephritis, GLOMERULONEPHRITIS AKUT, Glomerulonephritis akut
Japanese 急性糸球体腎炎, キュウセイシキュウタイジンエン
French GLOMERULO-NEPHRITE AIGUE, Glomérulonéphrite aiguë
Portuguese GLOMERULONEFRITE AGUDA, Glomerulonefrite aguda
Spanish GLOMERULONEFRITIS AGUDA, glomerulonefritis aguda, SAI (trastorno), glomerulonefritis aguda, SAI, glomerulonefritis aguda (trastorno), glomerulonefritis aguda, Glomerulonefritis aguda
Czech Akutní glomerulonefritida
Hungarian Acut glomerulonephritis, acut glomerulonephritis
Dutch acuut; glomerulonefritis, glomerulonefritis; acuut, acute glomerulonefritis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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