Pharmacology Book

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Vitamin B6

Aka: Vitamin B6, Pyridoxine, Pyridoxal, Pyridoxamine
  1. Preparations: Food Sources
    1. Meat
    2. Poultry
    3. Fish
    4. Bananas
    5. Bran
    6. Nuts
    7. Whole-grain bread
    8. Cereals
    9. Soybeans
    10. Vegetables
  2. Causes: Vitamin B6 Deficiency
    1. Medication Causes of Vitamin B6 Deficiency
      1. Isoniazid (INH)
      2. Levodopa
    2. Signs of Vitamin B6 Deficiency
      1. Glossitis
      2. Peripheral Neuropathy
      3. Dementia
  3. Efficacy: Potential benefit of Vitamin B6
    1. May lower Coronary Artery Disease risk
      1. Based on retrospective studies
      2. Higher B6 intake associated with lower Homocysteine
    2. References
      1. Rimm (1998) JAMA 279:359 [PubMed]

Pyridoxal (C0034263)

Definition (MSH) The 4-carboxyaldehyde form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109) , Vitamin (T127)
MSH D011730
SnomedCT 430926008
LNC LP28588-9, MTHU014350
English Pyridoxal, 4-Pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl-, Pyridoxal (substance), 4-Pyridinecarboxaldehyde, 3-Hydroxy-5-(hydroxymethyl)-2-methyl-, 3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde, Pyridoxaldehyde, 2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine, 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde, Pyridoxal [Chemical/Ingredient], pyridoxal, PYRIDOXAL
Swedish Pyridoxal
Czech pyridoxal
Finnish Pyridoksaali
Russian PIRIDOKSAL', ПИРИДОКСАЛЬ
Spanish piridoxal (sustancia), piridoxal, Piridoxal
Polish Pirydoksal
Norwegian Not Translated[Pyridoxal]
French Pyridoxal
German Pyridoxal
Italian Piridoxal
Portuguese Piridoxal
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Pyridoxamine (C0034268)

Definition (MSH) The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109) , Vitamin (T127)
MSH D011733
SnomedCT 430632000, 259662009, 40869001
English Pyridoxamine, pyridoxamine, 3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, Pyridoxamine (substance), Pyridoxamine [Chemical/Ingredient]
Swedish Pyridoxamin
Czech pyridoxamin
Finnish Pyridoksamiini
Russian PIRIDOKSAMINFOSFAT, PIRIDOKSAMIN, ПИРИДОКСАМИН, ПИРИДОКСАМИНФОСФАТ
Spanish piridoxamina, piridoxamina (sustancia), Piridoxamina
Polish Pirydoksamina
French Pyridoxamine
German Pyridoxamin
Italian Piridossamina
Portuguese Piridoxamina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


pyridoxine (C0034272)

Definition (NCI_NCI-GLOSS) A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Pyridoxine helps keep nerves and skin healthy, fight infections, keep blood sugar levels normal, produce red blood cells, and some enzymes work properly. Pyridoxine is a group of related compounds (pyridoxine, pyridoxal, and pyridoxamine) found in cereals, beans, peas, nuts, meat, poultry, fish, eggs, and bananas. It is water-soluble (can dissolve in water). Not enough pyridoxine can cause mouth and tongue sores and nervous disorders. Pyridoxine is being studied in the prevention of hand-foot syndrome (a disorder caused by certain anticancer drugs and marked by pain, swelling, numbness, tingling, or redness of the hands or feet).
Definition (MSH) The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Concepts Organic Chemical (T109) , Vitamin (T127) , Pharmacologic Substance (T121)
MSH D011736
SnomedCT 259662009, 430469009, 36944009, 40869001
LNC LP32568-5, LP15842-5, MTHU012245
English Pyridoxine, Pyridoxol, 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, pyridoxol, vitamin B6 (pyridoxine), Pyridoxine (substance), Pyridoxine [Chemical/Ingredient], PYRIDOXINE, pyridoxin, Pyridoxin, pyridoxine (vit B6), Pyridoxine preparation, Pyridoxine preparation (product), Pyridoxine preparation (substance), pyridoxine
Swedish Pyridoxin
Czech vitamin B6, pyridoxin
Finnish Pyridoksiini
Russian PIRIDOKSIN, ПИРИДОКСИН
Japanese ピリドキソール, ピリドキシン, アデルミン
Spanish piridoxina, piridoxina (sustancia), preparado con piridoxina (producto), piridoxina (producto), preparado con piridoxina, preparado de piridoxina (sustancia), Piridoxina
Italian Piridossolo, Piridossina
Polish Adermina, Pirydoksyna
French Adermine, Pyridoxine
German Pyridoxin
Portuguese Piridoxina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Vitamin B6 (C0087162)

Definition (NCI) A group of water-soluble vitamins essential for metabolism and normal physiological functions. B6 vitamins, including pyridoxine, pyridoxal, and pyridoxamine, are converted in vivo to pyridoxal phosphate, a cofactor necessary for the synthesis of amino acids, neurotransmitters, and sphingolipids. More than 100 enzymes involved in protein metabolism require vitamin B6 as a cofactor. Vitamin B6 is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels. Vitamin B6 is found in a wide variety of foods including cereals, beans, meat, poultry, fish, and some fruits and vegetables. (NCI04)
Definition (NCI_CRCH) Class of water-soluble vitamins that are coenzymes in the metabolism of amino acids, glycogen, and sphingoid bases. (DRI)
Definition (NCI_NCI-GLOSS) A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Vitamin B6 helps keep nerves and skin healthy, fight infections, keep blood sugar levels normal, produce red blood cells, and some enzymes work properly. Vitamin B6 is a group of related compounds (pyridoxine, pyridoxal, and pyridoxamine) found in cereals, beans, peas, nuts, meat, poultry, fish, eggs, and bananas. It is water-soluble (can dissolve in water). Not enough vitamin B6 can cause mouth and tongue sores and nervous disorders. Vitamin B6 is being studied in the prevention of hand-foot syndrome (a disorder caused by certain anticancer drugs and marked by pain, swelling, numbness, tingling, or redness of the hands or feet).
Definition (MSH) VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.
Definition (CSP) group of water soluble B vitamins based on a polyhydroxy substituted pyridine structure, whose phosphate derivatives are important coenzymes in aminoacid metabolism.
Concepts Organic Chemical (T109) , Vitamin (T127) , Pharmacologic Substance (T121)
MSH D025101
SnomedCT 19315007, 40869001, 259662009, 430469009, 36944009
LNC LP31694-0
English Vitamin B 6, Vitamin B6, vitamin B6, Vitamin B6 (substance) [Ambiguous], Vitamin B<sub>6</sub> (substance) [Ambiguous], Vitamin B<sub>6</sub> preparation, vitamin-B6, B6 vitamin, VITAMIN B A 06, vitamin B6 (medication), Vitamin B>6<, Vitamin B<sub>6</sub>, Vitamin B 6 [Chemical/Ingredient], vit b6, Vitamin B>6< (substance), Vitamin B<sub>6</sub> (substance), Vitamin B-6, Vitamin B6 preparation, Vitamin B>6< preparation, Vitamin B6 (substance), VIT-B6, Vitamin B>6< (substance) [Ambiguous], VIT B6, VITAMIN B6
Swedish Vitamin B6
Czech vitamin B 6
Finnish B6-vitamiini
Russian VITAMIN B 6, VITAMIN B6, ВИТАМИН B 6, ВИТАМИН B6
Spanish vitamina B6 (concepto no activo), vitamina B<sub>6</sub>, vitamina B<sub>6</sub> (concepto no activo), preparado con vitamina B<sub>6</sub>, preparado con vitamina B>6<, preparado con vitamina B6, vitamina B>6< (sustancia), vitamina B<sub>6</sub> (sustancia), Vitamina B6, vitamina B6 (sustancia), vitamina B6, vitamina B>6< (concepto no activo), vitamina B>6<, Vitamina B 6
German VITAMIN B A 06, Vitamin B6
Polish Witamina B6
Japanese ビタミンB6, アクタミン B6
Norwegian Not Translated[Vitamin B 6]
Portuguese Vitamina B6, Vitamina B 6
French Vitamine B6
Italian Vitamina B6
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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