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Omega-3 Fatty Acid Supplement

Aka: Omega-3 Fatty Acid Supplement, Fish Oil Supplement
  1. See Also
    1. Omega-3 Fatty Acid
  2. Preparations: Supplements (OTC)
    1. Supplement sources
      1. Cod liver oil
      2. Standard fish body oil
      3. Omega-3 Fatty Acid concentrate
    2. Supplement Capsules (1 gram)
      1. Eicosapentaenoic Acid (EPA): 180 mg
      2. Docosahexaenoic Acid (DHA): 120 mg
    3. Liquid
      1. Variable concentrations per manufacturer
    4. Food sources for acquiring in diet
      1. See Omega-3 Fatty Acid
  3. Preparations: Prescriptions
    1. Lovaza
      1. Contents (per 1 gram capsule)
        1. EPA 465 mg
        2. DHA 375 mg
      2. Efficacy (4 gram/day dose)
        1. Lowers Triglycerides 45%
        2. Risk of increased LDL Cholesterol
    2. Vascepa
      1. Contents (per 1 gram capsule)
        1. EPA 1000 mg
      2. Efficacy (4 gram/day dose)
        1. Lowers Triglycerides 27%
    3. References
      1. (2013) Presc Lett 20(1):1-2
      2. Ballantyne (2012) Am J Cardiol 110(7):984-92 [PubMed]
  4. Dosing
    1. Standard dosing: 1 gram capsule or equivalent liquid daily
      1. Coronary Artery Disease Prevention
      2. Does not appear effective (at 1 g dose) for CAD primary prevention in those without CAD
        1. Halim (2012) Ann Intern Med 157(4):JC2-3 [PubMed]
    2. Higher dose: 2-4 grams per day
      1. Hypertriglyceridemia
      2. Currently being researched as to benefits and risks
        1. Hypertension
        2. Rheumatoid Arthritis
  5. Efficacy
    1. See Omega-3 Fatty Acid
  6. Adverse Effects
    1. Well tolerated in most patients
    2. Fish after-taste
    3. Gastrointestinal upset
    4. Prolonged Bleeding Time
    5. Increased LDL Cholesterol
    6. Mercury Poisoning risk (depending on source of extract)
  7. References
    1. Covington (2004) Am Fam Physician 70(1):133-40 [PubMed]

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