Pharmacology Book

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Ibuprofen

Aka: Ibuprofen, Motrin, Advil, Nuprin
  1. Indications
    1. Fever
    2. Analgesia
  2. Mechanism: NSAID - Propionic Acid
    1. Strong Analgesic action
    2. Moderate anti-inflammatory action (Dose >= 600 mg)
  3. Supplied
    1. Suspension: 100 mg/5ml
    2. Chewables: 50 mg, 100 mg
    3. Oral drops: 40 mg/ml
    4. Tablets: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg
  4. Dosing: Children older than age 6 months
    1. Dose: 5-10 mg/kg PO every 6 to 8 hours
  5. Dosing: Adult
    1. Dose: 400 to 800 mg orally three to four times daily
    2. Maximum: 3200 mg/day
  6. Contraindications
    1. Avoid in age under 6 months old
  7. Adverse Effects
    1. See NSAID Gastrointestinal Adverse Effects
    2. See NSAID Renal Adverse Effects
Medication Costs
Ibuprofen (on 6/18/2017 at Walmart.com)
Ibuprofen 100mg/5ml susp #120 ml for $4.00 $0.03 each
Ibuprofen 100mg/5ml susp #360 ml for $10.00 $0.03 each
Ibuprofen 400mg #90 tablets for $4.00 $0.04 each
Ibuprofen 400mg #270 tablets for $10.00 $0.04 each
Ibuprofen 600mg #60 tablets for $4.00 $0.07 each
Ibuprofen 600mg #180 tablets for $10.00 $0.06 each
Ibuprofen 800mg #30 tablets for $4.00 $0.13 each
Ibuprofen 800mg #90 tablets for $10.00 $0.11 each
ibuprofen (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
IBUPROFEN 100 MG/5 ML SUSP Generic OTC $0.03 per ml
IBUPROFEN 200 MG CAPLET Generic OTC $0.03 each
IBUPROFEN 200 MG SOFTGEL Generic OTC $0.08 each
IBUPROFEN 200 MG TABLET Generic OTC $0.03 each
IBUPROFEN 400 MG TABLET Generic $0.04 each
IBUPROFEN 600 MG TABLET Generic $0.05 each
IBUPROFEN 800 MG TABLET Generic $0.06 each
IBUPROFEN COLD-SINUS CPLT Generic OTC $0.17 each
IBUPROFEN JR STR 100 MG CHEW Generic OTC $0.14 each
IBUPROFEN JR STR 100 MG TB CHW Generic OTC $0.14 each
IBUPROFEN PM CAPLET Generic OTC $0.12 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Ibuprofen (C0020740)

Definition (CHV) a chemical substance
Definition (CHV) a chemical substance
Definition (NCI) A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)
Definition (NCI_NCI-GLOSS) A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
Definition (MSH) A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.
Definition (CSP) nonsteroidal analgesic, antipyretic and anti-inflammatory agent that is a propionic acid derivative.
Definition (PDQ) A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40475&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C561" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007052
SnomedCT 329955004, 329651005, 363606004, 322295006, 38268001, 387207008
LNC LP16165-0, MTHU004262, LA14347-1
English Ibuprofen, alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid, Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, Ibuprofen [cns analgesic], Ibuprofen [cns analgesic] [see j28..], Ibuprofen [musc-skel], Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-, p-Isobutylhydratropic Acid, ibuprofen, Ibuprofen [musculoskeletal use], Ibuprofen product, ibuprofen (OTC), ibuprofen (medication), Ibuprofen PMR, Ibuprofen [musc-skel use 2], Ibuprofen [musculoskeletal use 2], non-prescription ibuprofen, non-prescription ibuprofen (medication), IBUPROFEN, Ibuprofen [Chemical/Ingredient], ibuprofen products, Ibuprofen product (substance), Ibuprofen [cns analgesic] [see j28..] (product), Ibuprofen [musculoskeletal use] (product), Ibuprofen [musculoskeletal use 2] (product), (.+ -.)-p-Isobutylhydratropic acid, Propionic acid-ibuprofen, p-Isobutylhydratropic acid, Ibuprofen (product), Ibuprofen (substance), Ibuprofen [cns analgesic] [see j28..] (substance), Ibuprofen [musculoskeletal use 2] (substance), Ibuprofen [musculoskeletal use] (substance)
Swedish Ibuprofen
Czech ibuprofen
Finnish Ibuprofeeni
Russian IBUPROFEN, ИБУПРОФЕН
Japanese イブプロフェン
Polish Ibuprofen, Brufen
Norwegian Ibuprofen
Spanish ibuprofeno [uso musculoesquelético], ibuprofeno [uso musculoesquelético 2], ibuprofeno [analgésico de acción central] [véase j28..] (producto), ibuprofeno [analgésico de acción central] [véase j28..], ibuprofeno [uso musculoesquelético 2] (producto), ibuprofeno [uso musculoesquelético] (producto), ibuprofeno (producto), ibuprofeno (sustancia), ibuprofeno, ácido p-isobutilhidratrópico, Ibuprofeno
French Ibuprofène
German Ibuprofen
Italian Ibuprofene
Portuguese Ibuprofeno
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Advil (C0593507)

Definition (CHV) brand name of a pain killer drug
Definition (CHV) brand name of a pain killer drug
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Advil, advil [brand name], advil
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Motrin (C0699203)

Definition (CHV) brand name of ibuprofen
Definition (CHV) brand name of ibuprofen
Definition (CHV) brand name of ibuprofen
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007052
English Motrin IB, motrin [brand name], motrin ib, motrin, Motrin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Nuprin (C0699205)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D007052
English nuprin, Nuprin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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