Pharmacology Book

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Capsaicin

Aka: Capsaicin, Zostrix
  1. Indications
    1. Postherpetic Neuralgia
  2. Mechanism
    1. Derived from jalapeno peppers
    2. Depletes Substance P from pain fibers
    3. Requires frequent and repeat applications for affect
    4. Inconsistent use not effective
  3. Dose: Capsaicin Cream (OTC)
    1. Apply Capsaicin cream (0,025% to 0.075%) to affected area 3-5 times daily
  4. Dose: Capsaicin Patch (high dose - 8%)
    1. Applied in office
    2. Pre-treat area by applying 4% Lidocaine cream for 60 minutes
    3. Check area for anesthesia following application
    4. Apply Capsaicin 8% cream with gloves and leave on for 60 minutes
    5. Wash off after 1 hour
  5. Adverse effects
    1. Burning sensation on initial application
    2. Increased pain for up to first week of application
  6. Precautions
    1. Wash hands thoroughly after Capsaicin application
Medication Costs
capsaicin (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
CAPSAICIN 0.025% CREAM Generic OTC $0.07 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Capsaicin (C0006931)

Definition (NCI_NCI-GLOSS) A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. Also being studied for controlling mucositis pain after chemotherapy and radiation therapy.
Definition (NCI) A chili pepper extract with analgesic properties. Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons. Used topically, capsaicin aids in controlling peripheral nerve pain. This agent has been used experimentally to manipulate substance P and other tachykinins. In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis.
Definition (NCI_CRCH) Capsaicinoid compound with side chain CO(CH2)4(CH)2CH(CH3)2. The chemical structure is CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC.
Definition (CSP) N-(4-hydroxy-3-methoxyphenylmethyl) -8-methyl-6-nonenamide; chili pepper extract and neuropeptide releasing agent selective for primary sensory peripheral neurons, used to experimentally manipulate substance P and other tachykinins, and as an analgesic for Herpes zoster infection.
Definition (MSH) An alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.
Concepts Pharmacologic Substance (T121) , Lipid (T119)
MSH D002211
SnomedCT 400416009, 95995002
English 8-Methyl-N-Vanillyl-6-Nonenamide, Capsaicin, Capsaicine, 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (E)-, (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide, N-(4-hydroxy-3-methoxyphenylmethyl) -8-Methyl-6-Nonenamide, 8 Methyl N Vanillyl 6 Nonenamide, CAPSAICIN, capsaicin, Capsaicin [Chemical/Ingredient], capsaicine, (E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide, Capsaicin (product), Capsaicin (substance)
Swedish Kapsaicin
Czech kapsaicin
Finnish Kapsaisiini
German Trans-8-Methyl-N-vanillyl- 6-nonensäureamid, Capsaicin
Russian KAPSAITSIN, КАПСАИЦИН
Japanese カプサイシン
French N-(4-Hydroxy-3-méthoxybenzyl)-8-méthylnon-6-énamide, 8-Méthyl-N-vanillyl-non-6-énamide, N-(4-Hydroxy-3-méthoxybenzyl)-8-méthyl-non-6-énamide, Capsaïcine
Croatian KAPSAICIN
Polish Kapsaicyna
Spanish capsaicina (producto), capsaicina (sustancia), capsaicina, Capsaicina
Italian Capsaicina
Portuguese Capsaicina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Zostrix (C0308191)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002211
English Zostrix Neuropathy, zostrix, Link Brand of Capsaicin, Medicis Brand of Capsaicin, Zostrix
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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