Pharmacology Book

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Myoinositol

Aka: Myoinositol, Inositol
  1. Physiology
    1. Simple carbohydrate metabolized to Phosphatidylinositol
    2. Acts as second messenger to stimulate calcium release
    3. No known deficiency states in humans
  2. Indications
    1. Anxiety Disorder
      1. Panic Disorder
      2. Obsessive Compulsive Disorder (possibly)
    2. Other purported benefits
      1. May improve neural function in Diabetes Mellitus
  3. Preparations: Dietary sources (B Vitamin Complex part)
    1. Beans
    2. Citrus fruit
    3. Nuts
    4. Rice
    5. Veal
    6. Pork
    7. Wheat germ
  4. Dosing
    1. Panic Disorder: 12-18 grams daily
  5. Efficacy
    1. Effective in Panic Disorder
      1. Benjamin (1995) Am J Psychiatry 152:1084-6 [PubMed]
      2. Palatnik (2001) J Clin Psychopharmacol 21:335-9 [PubMed]
    2. Possibly effective in Obsessive-Compulsive Disorder
      1. Fux (1996) Am J Psychiatry 153:1219-21 [PubMed]

Inositol (C0021547)

Definition (NCI) A natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation. (NCI04)
Definition (NCI_NCI-GLOSS) A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Myoinositol helps cells make membranes and respond to messages from their environment. It has the same chemical formula as glucose (the chief source of energy for living organisms) but has a different arrangement of atoms. It is found in beans, peas, brown rice, wheat bran and nuts. It is water-soluble (can dissolve in water) and must be taken in every day. Myoinositol is being studied in the prevention of cancer.
Definition (MSH) An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
Definition (CSP) cyclic sugar alcohol, the fully hydroxylated derivative of cyclohexane, occurring naturally in a variety of stereoisomers, most commonly, the myo-isomer, myoinositol, a member of the vitamin B complex and a component of phosphatidylinositols.
Definition (PDQ) A natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=305828&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=305828&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28163" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Carbohydrate (T118) , Vitamin (T127)
MSH D007294
SnomedCT 386946007, 72164009, 108960004
LNC LP64093-5
English Chiro-Inositol, Inositol, Mesoinositol, Myoinositol, Chiro Inositol, cis-1,2,3,5-trans-4,6-Cyclohexanehexol, myo-Inositol, Cyclohexanehexol, dietary supplements inositol, inositol (medication), Myo-inositol, Inositol [Chemical/Ingredient], myoinositol, chiro-inositol, inositol, INOSITOL, Inositol preparation (substance), Anti-alopecia factor, Inose, Inositol product, Inositol (substance), Inositol preparation (product), Inositol preparation, myo-inositol
Swedish Inositol
Czech inositol
Finnish Inositoli
French Cyclohexanehexol, myo-Inositol, méso-Inositol, Inositol
Italian Chiro-inositolo, Mioinositolo, Mesoinositolo, Inositolo
Russian RIBOKSIN, INOZITOL, MIOINOZITOL, INOZIT, MIOINOZIT, ИНОЗИТ, ИНОЗИТОЛ, МИОИНОЗИТ, МИОИНОЗИТОЛ, РИБОКСИН
Spanish inositol (producto), preparado con inositol (producto), preparado con inositol, preparado de inositol (sustancia), preparado de inositol, factor antialopecia, inosa, inositol (sustancia), inositol, Inositol, Mioinositol
Polish Cykloheksanoheksaol, Inozytol
Japanese イノシット, イノシトール, シクロヘキサンヘキソール, シクロヘキシトール, ミオイノシトール
German Inositol, Inosit, Myoinositol, Myoinosit
Portuguese Inositol, Mioinositol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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