Pharmacology Book

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Don Quai

Aka: Don Quai, Dong Quai, Angelica sinensis
  1. Current uses
    1. Premenstrual Syndrome
    2. Irregular Menses
    3. Infertility
    4. Menopause
  2. Contraindications
    1. Anticoagulant medication
    2. Bleeding Diathesis (natural coumarins)
  3. Efficacy
    1. Herb no better than Placebo for menopausal symptoms
      1. Double-blind Placebo control (n=71 postmenopausal)
      2. Dong Quai 1.5 g tid for 24 weeks
    2. References
      1. Hirata (1997) Fertil Steril 68:981-6 [PubMed]
  4. Adverse Effects
    1. Psoralen effects
      1. Photosensitization
      2. Dermatitis
    2. Coumarin-like derivatives
      1. May increase bleeding risk

Angelica sinensis (C0950081)

Definition (MSH) A plant species of the family APIACEAE that is the source of dong quai.
Concepts Plant (T002)
MSH D029971
Swedish Angelica sinensis
Czech Angelica sinensis, děhel čínský
Finnish Angelica sinensis
Spanish Angelica sinensis
French Angélique chinoise, Angelica sinensis, Dang Gui, Dang Qui, Dong Quai, Tang Kuei
English Angelica sinenses, sinenses, Angelica, sinensis, Angelica, dong quai, angelica sinensis, Angelica sinensis, Chinese angelica, dong gui, Angelica sinensis (Oliv.) Diels
Polish Angelica sinensis
Korean 당귀
Norwegian Dong quai, Kinesisk kvann, Angelica sinensis
German Angelica sinensis
Italian Angelica sinensis
Russian ANGELICA SINENSIS
Dutch Angelica sinensis
Portuguese Angelica sinensis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Angelica sinensis preparation (C1122975)

Definition (PDQ) An herbal extract derived from the root of the plant Angelica sinensis with possible antiinflammatory, antispasmodic, vasodilatory, estrogenic, and antitumor activities. Angelica sinensis contains volatile oils, including safrole, isosafrole, and n-butylphthalide; coumarin derivatives, including psoralens, bergapten, osthol, imperatorin, and oxypeucedanin; and ferulic acid. The coumarin derivatives in this agent may vasodilate and relax smooth muscle and may exhibit additive anticoagulant effects. Ferulic acid, a phenolic phytochemical present in plant cell walls, may neutralize free radicals such as reactive oxygen species.In addition, Angelica sinensis extract has been shown to inhibit the growth and induce apoptosis of glioblastoma mutltiforme brain tumor cells through p53-dependent and p53-independent pathways. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=467927&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=467927&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60817" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C109695
SnomedCT 412176007
English Dong Quai Extract, Dong Quai Root Extract, Dong Quai Root, Dong Quai, dong quai, dong quai (medication), dong quai [Chemical/Ingredient], dong quai root, Angelica sinensis preparation, Angelica sinensis extract (substance), Angelica sinensis extract, Dong quai extract, DONG QUAI
Spanish extracto de Angelica sinensis (sustancia), extracto de Angelica sinensis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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