Neurology Book

http://www.fpnotebook.com/

Rivastigmine

Aka: Rivastigmine, Exelon
  1. See Also
    1. Acetylcholinesterase Inhibitor
    2. Dementia
    3. Dementia Management
    4. Donepezil (Aricept)
    5. Galantamine (Reminyl)
  2. Indications
    1. Alzheimer Disease
    2. Lewy Body Dementia
  3. Mechanism
    1. See Acetylcholinesterase Inhibitor
    2. Carbamate-based noncompetitive Cholinesterase Inhibitor
    3. Inhibits butyrylcholinesterase and acetylcholinesterase
    4. Increases Cholinergic transmission
  4. Pharmacokinetics: Oral Route
    1. Peak: 1 hour
    2. Duration: 10 hours
  5. Drug Interactions
    1. No significant Drug Interactions
  6. Efficacy
    1. Modestly improves scores on neuropsychological tests
    2. Benefits decrease after 40 weeks of treatment
  7. Adverse Effects
    1. See Acetylcholinesterase Inhibitor
    2. Specific adverse effects reported for Rivastigmine, not seen with other Acetylcholinesterase Inhibitors
      1. Abdominal Pain
      2. Atrial Fibrillation
      3. Myocardial Infarction
  8. Dosing
    1. Oral Route
      1. Initial: 1.5 mg orally twice daily with food for at least 2 weeks (4 weeks for Lewy Body Dementia)
      2. Next: 3 mg orally twice daily with food for at least 2 weeks (4 weeks for Lewy Body Dementia)
      3. Next: 4.5 mg orally twice daily with food for at least 2 weeks (4 weeks for Lewy Body Dementia)
      4. Next: 6 mg orally twice daily with food
    2. Transdermal Patch
      1. Initial: 4.6 mg patch every 24 hours for at least 4 weeks
      2. Next: 9.5 mg patch every 24 hours for at least 4 weeks
      3. Next: 13.3 mg patch every 24 hours
  9. References
    1. (2000) Med Lett Drugs Ther 42(1089):93-4 [PubMed]
    2. Corey-Bloom (1998) Int J Geriatr Psychopharm 1:55 [PubMed]
    3. Epperly (2017) Am Fam Physician 95(12): 771-8 [PubMed]
    4. Rosler (1999) BMJ 318:633 [PubMed]
Medication Costs
rivastigmine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
RIVASTIGMINE 1.5 MG CAPSULE Generic $0.99 each
RIVASTIGMINE 13.3 MG/24HR PTCH Generic $7.45 each
RIVASTIGMINE 3 MG CAPSULE Generic $1.00 each
RIVASTIGMINE 4.5 MG CAPSULE Generic $0.93 each
RIVASTIGMINE 4.6 MG/24HR PATCH Generic $7.53 each
RIVASTIGMINE 6 MG CAPSULE Generic $0.88 each
RIVASTIGMINE 9.5 MG/24HR PATCH Generic $7.35 each
exelon (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing)
EXELON 13.3 MG/24HR PATCH Generic $7.45 each
EXELON 4.6 MG/24HR PATCH Generic $7.53 each
EXELON 9.5 MG/24HR PATCH Generic $7.35 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

rivastigmine (C0649350)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C072506
SnomedCT 323368009, 395868008
English (S)-N-ethyl-3-((1-dimethyl-amino)ethyl)-N-methylphenylcarbamate, Carbamic acid, ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl ester, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1), rivastigmine, rivastigmine (medication), RIVASTIGMINE, rivastigmine [Chemical/Ingredient], Rivastigmine, Rivastigmine (product), Rivastigmine (substance)
Spanish rivastigmina (producto), rivastigmina (sustancia), rivastigmina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Exelon (C0730987)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C072506
English Exelon, rivastigmine (Exelon), exelon
Sources
Derived from the NIH UMLS (Unified Medical Language System)


You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree