Neurology Book

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Muscarinic Agonist

Aka: Muscarinic Agonist, Pilocarpine, Salagen, Cevimeline, Evoxac
  1. Mechanism
    1. Cholinergic agonist acting at muscarinic receptors
  2. Indications
    1. Sjogren's SyndromeDry Eyes (and possibly Dry Mouth) refractory to general measures
  3. Contraindications
    1. Angle closure Glaucoma
    2. Uncontrolled Asthma
  4. Adverse effects
    1. Diaphoresis
    2. Decreased night vision
    3. Nonselective agents (Pilocarpine) may have cardiopulmonary effects
  5. Preparation: Pilocarpine (Salagen)
    1. Nonselective (may have cardiac or lung effects)
    2. Dose: 5 mg orally twice daily
  6. Preparation: Cevimeline (Evoxac)
    1. Selective for exocrine glands
    2. Dose: 30 mg orally three times daily
  7. References
    1. Fife (2002) Arch Intern Med 162(11): 1293-300 [PubMed]
    2. Ono (2004) Am J Ophthalmol 138(1): 6-17 [PubMed]
    3. Tsifetaki (2003) Ann Rheum Dis 62(12): 1204-7 [PubMed]
    4. Wu (2006) J Formos Med Assoc 105(10): 796-803 [PubMed]
Medication Costs
pilocarpine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
PILOCARPINE 1% EYE DROPS Generic $4.79 per ml
PILOCARPINE 2% EYE DROPS Generic $4.69 per ml
PILOCARPINE 4% EYE DROPS Generic $5.00 per ml
PILOCARPINE HCL 5 MG TABLET Generic $1.04 each
PILOCARPINE HCL 7.5 MG TABLET Generic $1.26 each
cevimeline (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
CEVIMELINE HCL 30 MG CAPSULE Generic $1.65 each
evoxac (on 4/7/2017 at Medicaid.Gov Pharmacy Drug pricing)
EVOXAC 30 MG CAPSULE Generic $1.65 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Muscarinic Agonists (C0242947)

Definition (MSH) Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. They may also be used to reduce heart rate.
Concepts Pharmacologic Substance (T121)
MSH D018721
English Agonist, Muscarinic, Agonist, Muscarinic Cholinergic, Agonists, Muscarinic, Agonists, Muscarinic Cholinergic, Cholinergic Agonist, Muscarinic, Cholinergic Agonists, Muscarinic, Muscarinic Agonist, Muscarinic Cholinergic Agonist, Muscarinic Cholinergic Agonists, CHOLINERGIC AG MUSCARINIC, MUSCARINIC AGON, CHOLINERGIC AGON MUSCARINIC, MUSCARINIC AG, muscarinic agonist, muscarinic agonists, Muscarinic Agonists, Cholinergic Muscarinic Agonists, Agonists, Cholinergic Muscarinic, Muscarinic Agonists, Cholinergic
French Agoniste muscarinique, Agonistes cholinergiques muscariniques, Agonistes muscariniques
Swedish Muskarinstimulerare
Czech muskarin - agonisté
Finnish Muskariiniagonistit
Italian Agonisti colinergici muscarinici, Agonista colinergico muscarinico, Agonista muscarinico, Agonisti muscarinici
Russian MUSKARINOVYE AGONISTY, KHOLINERGICHESKIE AGONISTY MUSKARINOVYE, МУСКАРИНОВЫЕ АГОНИСТЫ, ХОЛИНЕРГИЧЕСКИЕ АГОНИСТЫ МУСКАРИНОВЫЕ
Croatian MUSKARINSKI AGONISTI
Polish Agoniści cholinergiczni muskaryny, Agoniści muskaryny
Japanese ムスカリン作動剤, ムスカリンアゴニスト, ムスカリンコリン作用薬
German Cholinerge Agonisten, Muscarin-, Muscarinagonisten
Portuguese Agonistas Colinérgicos Muscarínicos, Agonistas Muscarínicos
Spanish Agonistas Colinérgicos Muscarínicos, Agonistas Muscarínicos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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