Neurology Book

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Eslicarbazepine

Aka: Eslicarbazepine, Aptiom
  1. Indications
    1. Adjunctive agent in Refractory Partial-Onset Seizures
    2. Bipolar Disorder
    3. Trigeminal Neuralgia
  2. Mechanism
    1. Antiepileptic
    2. Sodium channel blocker (similar to Carbamazepine and Oxcarbazepine)
  3. Dosing
    1. Normal Renal Function
      1. Initial: 400 mg orally once daily for 1 week
      2. Maintenance: 800 mg orally once daily
      3. Maximum dose: 1200 mg/day
    2. Decreased Renal Function to Creatinine Clearance <50 ml/min
      1. Initial: 200 mg orally once daily for 2 weeks
      2. Maintenance: 400 mg orally once daily
      3. Maximum dose: 600 mg/day
  4. Adverse Effects
    1. Dizziness
    2. Somnolence
    3. Headache
    4. Double Vision
  5. Drug Interactions
    1. Do not use with other similar Sodium channel blocker agents such as Carbamazepine and Oxcarbazepine
    2. Hormonal contraceptives
      1. Eslicarbazepine decreases the contraceptive efficacy
      2. Use alternative, non-hormonal agents or backup Contraception
  6. Resources
    1. Medscape
      1. http://reference.medscape.com/drug/aptiom-eslicarbazepine-acetate-999902
  7. References
    1. (2014) Presc Lett 21(11): 65
    2. Ben-Menachem (2010) Epilepsy Curr 10(1): 7–8 [PubMed]
Medication Costs
aptiom (on 4/19/2017 at Medicaid.Gov Pharmacy Drug pricing)
APTIOM 200 MG TABLET $26.79 each
APTIOM 400 MG TABLET $26.68 each
APTIOM 600 MG TABLET $26.66 each
APTIOM 800 MG TABLET $26.75 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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