Neurology Book

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Cognex

Aka: Cognex, Tacrine
  1. See Also
    1. Alzheimer's Disease
    2. Rivastigmine (Exelon)
    3. Donepezil (Aricept)
    4. Galantamine (Reminyl)
  2. Background
    1. Replaced by newer agents (e.g. Aricept) - avoid use due to hepatotoxicity risk
  3. Indications
    1. No longer used in U.S. due to hepatotoxicity risk
    2. Mild to Moderate Dementia (Folstein MMSE: 10-26)
  4. Mechanism
    1. First Acetylcholinesterase Inhibitor
    2. Other agents are now preferred
  5. Efficacy
    1. Response in 20% of patients
    2. Aricept offers similar efficacy and less toxicity
  6. Dosing
    1. Start at 10 mg PO qid for 4 weeks
    2. Increase to 20 mg PO qid for 4 weeks
    3. Titrate to maximum of 40 mg
  7. Adverse effects
    1. Hepatotoxicity
      1. Follow Liver Function Tests (esp. SGPT) every 2 weeks

Tacrine (C0039245)

Definition (MSH) A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
Definition (CSP) cholinesterase inhibitor that crosses the blood-brain barrier; has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and to improve cognitive performance in the treatment of Alzheimer's disease and other central nervous system disorders.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013619
SnomedCT 108494008, 373727000
LNC LP17860-5, MTHU024717
English 1,2,3,4-Tetrahydroaminoacridine, 9-Amino-1,2,3,4-Tetrahydroacridine, Tetrahydroaminoacridine, 1,2,3,4-Tetrahydro-9-acridinamine, tetrahydroaminoacridine, 9-Acridinamine, 1,2,3,4-tetrahydro-, TACRINE, THA, tacrine (medication), tacrine, Tacrine [Chemical/Ingredient], tha, Tacrine (product), Tacrine (substance), Tacrine
Swedish Takrin
Czech takrin
Finnish Takriini
Russian TETRAGIDROAMINOAKRIDIN, TAKRIN, ТАКРИН, ТЕТРАГИДРОАМИНОАКРИДИН
Japanese テトラハイドロアミノアクリジン, タクリン, テトラヒドロアミノアクリジン
Polish Takryna
Portuguese Tetra-Hidroaminoacridina, Tetraidroaminoacridina, Tacrina
Spanish tacrina (producto), tacrina (sustancia), tacrina, Tacrina, Tetrahidroaminoacridina
French Tacrine
German Tacrin, Tetrahydroaminoacridin
Italian Tacrina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Cognex (C0699954)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013619
English cognex, Cognex, Horizon Brand of Tacrine Hydrochloride, OTL Pharm Brand of Tacrine Hydrochloride, Parke Davis Brand of Tacrine Hydrochloride
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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