Neurology Book

Approach

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Tensilon Test

Aka: Tensilon Test, Edrophonium Test
  1. See Also
    1. Myasthenia Gravis
    2. Ice Pack Test
  2. Indications
    1. Ptosis evaluation in suspected Myasthenia Gravis
  3. Contraindications
    1. Elderly
    2. Coronary Artery Disease
    3. Asthma
  4. Adverse Effects
    1. Increased Salivation
    2. Abdominal cramping
    3. Bradycardia
    4. Bronchospasm
  5. Mechanism
    1. Edrophonium (Tensilon) is a rapid onset, short acting Acetylcholinesterase Inhibitor
  6. Preparation
    1. Consider telemetry monitoring
    2. Atropine 0.5 mg IV prn symptomatic Bradycardia
  7. Technique
    1. Edrophonium (10 mg/ml) 1 ml is drawn into a 1 cc syringe (tuberculin syringe)
    2. Inject edrophonium 2 mg (0.2 cc) IV every minute up to cummulative dose of 10 mg
    3. Stop when improvement in Ptosis is observed or 10 mg is reached (typically at 4-6 mg or 0.4 to 0.6 cc)
  8. Interpretation
    1. Ptosis improvement with edrophonium is suggestive of Myasthenia Gravis
  9. Efficacy
    1. Test Sensitivity: 80-90%
    2. False positives
      1. Motor Neuron disorders
      2. Brainstem tumor
      3. Compressive cranial Neuropathy
  10. References
    1. Daroff (1986) Arch Neurol 48:843 [PubMed]

Tensilon test (C1142121)

Concepts Diagnostic Procedure (T060)
SnomedCT 33981001
Italian Test all'edrofonio cloruro
English Tensilon test, Tensilon test (procedure), tensilon test, Edrophonium chloride test for myasthenia gravis, Tensilon test for myasthenia gravis, Edrophonium chloride test for myasthenia gravis (procedure), Edrophonium chloride test for myasthenia gravis (regime/therapy)
Japanese テンシロン試験, テンシロンシケン
Spanish prueba del cloruro de edrofonio para miastenia grave (régimen/tratamiento), prueba de Tensilon para la miastenia grave, prueba del cloruro de edrofonio para miastenia grave, Prueba con Tensilon, prueba del cloruro de edrofonio para miastenia grave (procedimiento)
Czech Test s podáváním přípravku Tensilon
Hungarian Tensilon vizsgálat
Portuguese Teste com Tensilon
Dutch tensilon test
French Epreuve au tensilon
German Tensilon-Test
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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