Pulmonology Book

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Rifapentine

Aka: Rifapentine, Priftin
  1. See Also
    1. Rifampin
  2. Class
    1. Rifamycin
      1. Inhibits Bacterial RNA polymerase
  3. Mechanism
    1. Long-acting Rifampin derivative
  4. Contraindications
    1. Children under age 2 years
    2. Latent Tuberculosis with suspected resistance to Isoniazid or Rifampin
    3. HIV patients on Antiretrovirals (due to lower drug levels and risk of resistance)
    4. Unknown safety in pregnancy
  5. Dosing
    1. Tuberculosis
      1. Part of multi-drug regimen; high risk of drug resistance Tb if used alone
      2. Rifapentine 600 mg orally twice weekly for 2 months then once weekly for 4 months
    2. Latent Tuberculosis
      1. See Latent Tuberculosis
  6. Adverse Effects
    1. See Rifampin
    2. Hyperuricemia
    3. Body secretion discoloration (orange to brown)
      1. Discolors urine and Contact Lenses
    4. Hepatotoxicity (uncommon)
    5. Thrombocytopenia
    6. Neutropenia (rare)
  7. Drug Interactions
    1. See Rifampin
    2. Metabolized by Cytochrome P-450 3A3/4
  8. Monitoring
    1. Baseline Liver Function Tests and clinical evaluations
  9. References
    1. (2011) MMWR Morb Mortal Wkly Rep 60(48): 1650-3 [PubMed]
    2. Hartman-Adams (2014) Am Fam Physician 89(11): 889-96 [PubMed]

rifapentine (C0073372)

Definition (NCI) A long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C018421
SnomedCT 108686006, 410831004
English 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)rifamycin SV, rifapentine, rifapentine (medication), rifapentine [Chemical/Ingredient], Rifapentine (substance), Rifapentine, Rifapentine (product), RIFAPENTINE
Spanish rifapentina (sustancia), rifapentina, rifapentina (producto)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Priftin (C0876758)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C018421
English Priftin, Aventis Behring brand of rifapentine
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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