Pulmonology Book

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Nonasthmatic Eosinophilic Bronchitis

Aka: Nonasthmatic Eosinophilic Bronchitis, Eosinophilic Bronchitis
  1. See Also
    1. Chronic Cough
  2. Epidemiology
    1. Emerging cause of Chronic Cough in pulmonology clinics
    2. Responsible for 10-30% of Chronic Cough cases referred to pulmonology
  3. Differential Diagnosis
    1. See Chronic Cough Causes
    2. Asthma
  4. Diagnosis
    1. Normal airway hyper-responsiveness (i.e. not Asthma)
      1. Normal Spirometry
      2. Normal airway responsiveness on methacholine inhalation test
    2. Sputum Eosinophilia (i.e. not Chronic Bronchitis)
      1. Induced Sputum (via saline nebulization) with 3% or more Eosinophils
    3. No signs variable airflow obstruction
  5. Management
    1. Does not respond to Inhaled Bronchodilators
    2. Eliminate Occupational Lung Disease and inhaled allergan exposures
    3. High-dose Inhaled Corticosteroids
    4. Brief initial course of Systemic Corticosteroids may be considered if Inhaled Corticosteroids ineffective
  6. References
    1. Brightling (1999) Am J Respir Crit Care Med 160(2): 406-10 [PubMed]
    2. Brightling (2010) Lung 188(suppl 1): S13-17 [PubMed]

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