Infectious Disease Book

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Penciclovir Cream

Aka: Penciclovir Cream, Penciclovir, Denavir
  1. Indications
    1. Herpes Labialis (Cold Sores)
  2. Dosing
    1. Penciclovir 1% Cream
    2. Start topical application at first symptoms
    3. Apply every 2 hours while awake for 4 days
  3. Efficacy
    1. Study n=1573, PCT showed significant improvement
      1. More than 0.5 days faster resolution, decreased pain
    2. Reference
      1. Spruance (1997) JAMA 277:1374-9 [PubMed]
Medication Costs
denavir (on 10/19/2016 at Medicaid.Gov Pharmacy Drug pricing)
DENAVIR 1% CREAM $143.08 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

penciclovir (C0164815)

Definition (NCI) A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C053539
SnomedCT 356191006, 333029001, 108918003, 386939003
LNC LP101038-0, MTHU036238
English 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine, penciclovir, Penciclovir [skin], penciclovir (medication), PENCICLOVIR, penciclovir [Chemical/Ingredient], 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-, 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Penciclovir [skin] (product), Penciclovir, Penciclovir (product), Penciclovir (substance), Penciclovir [skin] (substance)
Spanish penciclovir (uso dermatológico), penciclovir (uso dermatológico) (producto), penciclovir (piel) (producto), penciclovir (piel), penciclovir (producto), penciclovir (sustancia), penciclovir
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Denavir (C0719742)

Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C053539
English Denavir, denavir, Vectavir, Novartis brand of penciclovir, SB-CH brand of penciclovir
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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