Infectious Disease Book

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Acute Nitrofurantoin Pulmonary Toxicity

Aka: Acute Nitrofurantoin Pulmonary Toxicity
  1. See Also
    1. Nitrofurantoin
  2. Epidemiology
    1. More common in younger patients
  3. Symptoms
    1. Fever
    2. Cough
    3. Chest Pain
    4. Fever
    5. Rash (variably present)
  4. Labs
    1. Complete Blood Count
      1. Eosinophilia
  5. Imaging: Chest XRay
    1. Diffuse Pulmonary Infiltrates
  6. Differential Diagnosis
    1. Idiopathic Pulmonary Fibrosis
      1. Occurs with Nitrofurantoin and GFR <30 ml/min
  7. Management
    1. Immediate Nitrofurantoin cessation (resolves on stopping Nitrofurantoin)
    2. Consider Corticosteroids
  8. References
    1. Vahid (2006) Internet J Pulm Med 6(2): 1531-2984

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