Infectious Disease Book

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Anti-streptolysin O titer

Aka: Anti-streptolysin O titer, Anti-streptococcus O titer, ASO Titer
  1. Method
    1. Latex agglutination test
    2. Identifies serum Antibody to streptolysin O
      1. Group A Streptococcus Oxygen labile hemolysin
  2. Mechanism
    1. Sensitive for acute streptococcal infection
      1. Early Penicillin prevents ASO rise
    2. Increases within one week of infection
    3. Peaks 2-4 weeks after infection
  3. Normal
    1. Age 5-12 years: <333 I.U.
    2. Young Adults: <200 I.U.
  4. Increased
    1. Streptococcus respiratory infection
    2. Acute Rheumatic Fever (80%)
    3. Acute Glomerulonephritis (95%)
      1. Membranoproliferative Glomerulonephritis (20%)
      2. Acute Poststreptococcal Glomerulonephritis (70%)

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