Infectious Disease Book

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Fever of Unknown Origin Examination

Aka: Fever of Unknown Origin Examination
  1. See Also
    1. Fever
    2. Fever of Unknown Origin
    3. Fever of Unknown Origin History
    4. Drug-Induced Fever
    5. Fever of Unknown Origin Causes
    6. Fever of Unknown Origin Causes by Age
    7. Fever in the Returning Traveler
    8. Fever of Unknown Origin Causes in Comorbid Conditions
    9. Fever of Unknown Origin History
  2. Signs: Skin findings suggestive of infectious pathology
    1. Petechiae or Purpura (Systemic Vasculitis)
    2. Seborrheic rash (Histiocytosis X)
    3. Perineal rash (Kawasaki's Disease)
    4. Pallor, Jaundice or soft skin (Hyperthyroidism)
    5. Sparse eyebrows (anhydrotic ectodermal dysplasia)
    6. Hair Loss or breakage (Systemic Lupus Erythematosus)
    7. Characteristic rashes
      1. Tick-borne infection (e.g. Lyme Disease)
      2. Herpes Simplex Virus
  3. Signs: Eye findings suggestive of infectious pathology
    1. Bulbar Conjunctivitis
      1. Kawasaki's Disease
      2. Leptospirosis
    2. Palpebral or Bulbar injection
      1. Systemic Lupus Erythematosus
      2. Tularemia
      3. Histoplasmosis
      4. Chlamydia
    3. Punctate Conjunctival Hemorrhages
      1. Bacterial Endocarditis
    4. No pupillary constrictor response
      1. Familial Dysautonomia
    5. Fundus lesions
      1. Toxoplasmosis
      2. Cytomegalovirus
      3. Papilledema
      4. Roth Spots
      5. Leptospirosis
    6. Uveitis
      1. Autoimmune disease
      2. Sarcoidosis
      3. Tuberculosis
      4. Toxoplasmosis
      5. Syphilis
      6. Leptospirosis
      7. Still's Disease
  4. Signs: Abdominal findings
    1. Hepatomegaly, Splenomegaly or abdominal mass
      1. Alcoholic Liver Disease
      2. Cancer
      3. Cytomegalovirus
      4. Epstein-Barr Virus
      5. Leukemia
      6. Lymphoma
  5. Signs: Musculoskeletal findings
    1. Joint Swelling or pain
      1. Inflammatory Bowel Disease
      2. Lyme Disease
    2. Bone findings suggestive of infectious pathology
      1. See Osteomyelitis
      2. Focal tenderness (assess for long bone Osteomyelitis)
  6. Signs: Lymph node findings suggestive of infectious pathology
    1. Generalized Lymphadenopathy
      1. Autoimmune cause
      2. Cat Scratch Disease
      3. Cytomegalovirus
      4. Epstein-Barr Virus
      5. Acute HIV Infection
    2. Localized or nontender adenopathy
      1. Malignancy
  7. Signs: Cardiac findings suggestive of infectious pathology
    1. Diastolic insufficiency murmurs
    2. Widened Pulse Pressure

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