Infectious Disease Book

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Neutropenic Fever Clinical Decision Rule

Aka: Neutropenic Fever Clinical Decision Rule, Multinational Association for Supportive Care in Cancer Risk Index, MASCC Risk Index
  1. See Also
    1. Neutropenic Fever
    2. Neutropenia
    3. CISNE Score
  2. Indications
    1. Assess risk in Neutropenic Fever
  3. Contraindications
    1. Children under age 16 years (have different rules for risk stratification)
  4. Criteria
    1. Neutropenic Fever symptom severity (choose one)
      1. No symptoms or Mild symptoms: 5 points
      2. Moderate symptoms: 3 points
    2. Hypotension not present: 5 points
    3. COPD not present: 4 points
    4. Solid tumor or non-fungal infection: 4 points
    5. Dehydration not present: 3 points
    6. Fever had onset as outpatient: 3 points
    7. Age under 60 years: 2 points
  5. Interpretation
    1. Total score >21: Low Risk (consider outpatient therapy)
    2. Total score <21: High Risk (inpatient therapy)
  6. References
    1. Hughes (2002) Clin Infect Dis 34:730-51 [PubMed]
    2. Klastersky (2000) J Clin Oncology 18(16): 3038-51 [PubMed]
    3. Talcott (1992) J Clin Oncol 10:316-22 [PubMed]

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