Infectious Disease Book

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Immunoglobulin

Aka: Immunoglobulin, Antibody, Monoclonal Antibody, Fragment Antigen Binding, Fragment Crystallizable, Ligand
  1. See Also
    1. Monoclonal Antibody-Mediated Chemotherapy
  2. Definitions
    1. Fragment Antigen Binding (Fab)
      1. Antibody region that recognizes and binds antigens
    2. Fragment Crystallizable (Fc)
      1. Antibody region that interacts with immune system components
      2. Endogenous Fc triggers Natural Killer Cells and complement cascade
      3. Synthetic monoclonal antibodies may bind Fc to toxins or radioisotopes in Chemotherapy
    3. Ligand
      1. Molecule that binds to a specific receptor
    4. Monoclonal Antibody
      1. Identical antibodies that are synthesized by a single immune cell type
      2. Synthesized in labs to be targeted at disease-specific molecules
        1. Targeted Cancer Therapy
        2. Rheumatoid Arthritis
        3. Inflammatory Bowel Disease
  3. Physiology: Immunoglobulin
    1. Structure: Immunoglobulin is composed of a 4 chain monomeric structure
      1. Two heavy chains (identical)
        1. Five heavy chain classes: M, D, E, A, and G1-4
      2. Two light chains (identical)
        1. Two light chain classes: kappa and lambda
  4. Types: Immunoglobulins
    1. IgA Immunoglobulin
    2. IgE Immunoglobulin
    3. IgM Immunoglobulin
    4. IgG Immunoglobulin
  5. References
    1. Bakerman (1984) ABCs of Interpretive Lab Data, p. 392

Antibodies (C0003241)

Definition (NCI_NCI-GLOSS) A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.
Definition (NCI) A type of protein made by B lymphocytes in response to a foreign substance (antigen). Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen.
Definition (CSP) infection-fighting protein molecule in blood or secretory fluids that tags, neutralizes, and helps destroy pathogenic microorganisms such as bacteria or viruses and toxins; they are generally known as immunoglobulins, and are made and secreted by B-lymphocytes in response to stimulation by antigens; each specific antibody binds only to the specific antigen that stimulated its production.
Definition (MSH) Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Concepts Immunologic Factor (T129) , Amino Acid, Peptide, or Protein (T116)
MSH D000906
SnomedCT 68498002
LNC LP39213-1, LP17809-2, LP20667-9, LP17807-6, LP38951-7, LP40096-7, MTHU003502, MTHU001898, MTHU003494
English Antibodies, Antibodies [Chemical/Ingredient], antibody, antibodies, Unidentified Ab, Little NOS Ab, NOS Ab, Unidentified Antibody, not otherwise specified Antibody, Little not otherwise specified Antibody, Antibody, Antibody (substance), Antibody, NOS, Ab
Swedish Antikroppar
Czech protilátky
Finnish Vasta-aineet
Russian ANTITELA, АНТИТЕЛА
Croatian ANTITIJELA
Latvian Not Translated[Antibodies]
Polish Przeciwciała
Norwegian Not Translated[Antibodies]
Spanish anticuerpo (sustancia), anticuerpo, Anticuerpos
French Anticorps
German Antikörper
Italian Anticorpi
Portuguese Anticorpos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Monoclonal Antibodies (C0003250)

Definition (MSH) Antibodies produced by a single clone of cells.
Definition (NCI) An antibody produced by a clone or genetically homogenous fast-growing cells i.e., hybridoma. Hybridoma cells are cloned to establish cell lines producing a specific antibody that is chemically and immunologically homogeneous. They are widely used in cancer detection, diagnosis, and treatment.
Definition (NCI_NCI-GLOSS) A type of protein made in the laboratory that can bind to substances in the body, including tumor cells. There are many kinds of monoclonal antibodies. Each monoclonal antibody is made to find one substance. Monoclonal antibodies are being used to treat some types of cancer and are being studied in the treatment of other types. They can be used alone or to carry drugs, toxins, or radioactive materials directly to a tumor.
Definition (CSP) homogeneous antibody that is produced by a clone of antibody forming cells and that binds with a single antigenic determinant.
Concepts Immunologic Factor (T129) , Amino Acid, Peptide, or Protein (T116)
MSH D000911
SnomedCT 312312006, 49616005
English Antibodies, Monoclonal, MoAB, Antibodies, Monoclonal [Chemical/Ingredient], Monoclonal antibodies, monoclonal antibody, Monoclonal antibody, Monoclonal antibody (substance), monoclonal antibodies, MAb, Monoclonal Antibody, Monoclonal Antibodies
Swedish Monoklonala antikroppar
Finnish Monoklonaaliset vasta-aineet
Russian ANTITELA MONOKLONAL'NYE, MONOKLONAL'NYE ANTITELA, АНТИТЕЛА МОНОКЛОНАЛЬНЫЕ, МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА
French Anticorps monoclonal, Anticorps monoclonaux
Croatian MONOKLONSKA PROTUTIJELA, PROTUTIJELA, MONOKLONSKA, ANTITIJELA, MONOKLONSKA
Czech monoklonální protilátky, protilátky monoklonální
Polish Przeciwciała monoklonalne
Japanese モノクローナル抗体, 抗体-モノクローナル, 単クローン性抗体, モノクロナール抗体, 単クローン抗体
Spanish anticuerpo monoclonal (sustancia), anticuerpo monoclonal, Anticuerpos Monoclonales
German Antikörper, monoklonale, Monoklonale Antikörper
Italian Anticorpi monoclonali
Portuguese Anticorpos Monoclonais
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Ligands (C0023688)

Definition (NCI) An ion, molecule or molecular group that binds to a substance to form a larger complex.(Dr. Joseph A. Thie)
Definition (MSH) A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Definition (CSP) molecule that binds to another molecule, especially a small molecule that binds specifically to a larger molecule.
Concepts Chemical (T103)
MSH D008024
French Ligands
Swedish Ligander
Czech ligandy
Finnish Ligandit
Russian LIGANDY, ЛИГАНДЫ
Croatian LIGANDI
English ligand, ligands, Ligand, Ligands
Polish Ligandy, Addenty
Spanish Ligantes, Ligandos
German Liganden
Italian Ligandi
Portuguese Ligantes
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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