Infectious Disease Book

Acid Fast Bacteria

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Glanders

Aka: Glanders
  1. Cause
    1. Burkholderia mallei (Malleomyces mallei)
      1. Formerly categorized as Pseudomonas
  2. Pathophysiology
    1. Gram Negative bacillus
    2. Previously only domesticated animal infection
      1. Horses, Mules, and Donkeys
      2. Historically contracted by animal handlers (rare)
      3. No naturally acquired human cases in last 60 years
    3. Aerosolized risk as a biological warfare agent
      1. Infection rate in those exposed to aerosol: 46%
    4. Incubation: 10-14 days after inhalation
  3. Symptoms (Septicemic form)
    1. Fever
    2. Rigors
    3. Night Sweats
    4. Myalgia
    5. Headache
    6. Pleuritic Chest Pain
    7. Photophobia
    8. Lacrimation
    9. Diarrhea
  4. Signs
    1. Acute (Septicemic form)
      1. Fever
      2. Cervical adenopathy
      3. Splenomegaly
      4. Rash
        1. Generalized papular or pustular eruptions
    2. Chronic form
      1. Rash
        1. Cutaneous and intramuscular abscess
      2. Nasal discharge and ulceration (50%)
  5. Labs
    1. Exudate Methylene blue stain
      1. Scant small bacilli
    2. Sputum Culture on meat nutrient mediums
    3. Complete Blood Count
      1. Mild Leukocytosis with Left Shift
  6. Radiology: Chest XRay
    1. Miliary Nodules (0.5 - 1.0 cm)
      1. Small, multiple Lung Abscesses
    2. Bronchopneumonia
    3. Lobar Pneumonia
    4. Necrotizing nodular lesions
  7. Course
    1. Uniformly fatal if untreated
  8. Complications
    1. Osteomyelitis
    2. Brain Abscess
    3. Meningitis
  9. Prevention
    1. No Vaccine
    2. Post-exposure Prophylaxis with Septra
    3. Environmental Decontamination with 0.5% Hypochlorite
  10. References
    1. (1998) Medical Management of Biological Casualties
      1. U.S. Army Medical Research Institute of ID

Glanders (C0017589)

Definition (CHV) a contagious disease of horses that can be transmitted to humans
Definition (CHV) a contagious disease of horses that can be transmitted to humans
Definition (CHV) a contagious disease of horses that can be transmitted to humans
Definition (MSH) A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.
Concepts Disease or Syndrome (T047)
MSH D005896
ICD9 024
ICD10 A24.0
SnomedCT 4639008, 35322000
Swedish Rots
Czech vozhřivka, Vozhřivka
Finnish Pseudomonas mallein aiheuttama räkätauti
Russian SAP, САП
English farcy, farcy (diagnosis), glanders, glanders (diagnosis), glanders due to infection by actinobacillus mallei, glanders due to infection by malleomyces mallei, glanders due to Burkholderia mallei (diagnosis), glanders due to Pseudomonas mallei (diagnosis), glanders due to Burkholderia mallei, glanders due to Malleomyces mallei, glanders due to Malleomyces mallei (diagnosis), glanders due to Actinobacillus mallei (diagnosis), glanders due to infection by Pseudomonas mallei, glanders due to Pseudomonas mallei, glanders due to infection by mallei, glanders due to infection by mallei (diagnosis), glanders due to Actinobacillus mallei, glanders due to infection by Burkholderia mallei, Malleus, Glanders [Disease/Finding], Farcy, Equine glanders, Farcy buds, Farcy cords, Farcy pipes, Infection due to Actinobacillus mallei, Infection due to Malleomyces mallei, Infection due to Pseudomonas mallei, Maliasmus, Malleus (glanders), Equina, Glanders (disorder), Glanders, malleus, Infection due to actinobacillus mallei, Infection due to malleomyces mallei
Korean 마비저
Italian Farcino, Morva
Dutch kwade droes, Droes, kwade, Kwade droes
Japanese バビソ, 馬鼻疽
Polish Nosacizna
Hungarian Takonykór
Norwegian Snive
Spanish brotes de muermo, infección por Actinobacillus mallei, infección por Malleomyces mallei, infección por Pseudomonas mallei, muermo (trastorno), muermo, Muermo
Portuguese Maleína, Mormo
French Morve
German Rotz, Malleus
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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