Hematology and Oncology Book

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Generalized Lymphadenopathy

Aka: Generalized Lymphadenopathy, Lymphadenopathy Causes, Lymphadenitis Causes
  1. See Also
    1. Medication Causes of Lymphadenopathy
    2. Lymphadenopathy of the Head and Neck
    3. Lymphadenopathy in the Febrile Returning Traveler
    4. Regional Lymphadenopathy
    5. Lymphadenopathy
  2. Causes: General Infectious Causes of Lymphadenopathy
    1. Common Infectious Causes
      1. Infectious Mononucleosis (Epstein-Barr Virus)
      2. Toxoplasmosis
      3. Cytomegalovirus
      4. Cat Scratch Disease (Cat Scratch Fever, Bartonella)
      5. Upper Respiratory Infections (e.g. Pharyngitis, Adenovirus)
      6. Tuberculosis
      7. Scarlet Fever
      8. Scabies
      9. Herpes Zoster virus (Shingles)
      10. Cellulitis, Impetigo and other Skin Infections (Streptococcus and Staphylococcus)
    2. Sexually Transmitted Disease Causes of Lymphadenopathy
      1. Hepatitis B
      2. Acute Retroviral Syndrome in HIV Infection
      3. See Lymphadenopathy in HIV
      4. Primary Syphilis and Secondary Syphilis
      5. Lymphogranuloma venereum
      6. Chancroid
    3. Less Common Infectious Causes
      1. Miscellaneous fungal and Helminth infections
      2. Fungal Lung Infections (Histoplasmosis, Coccidioidomycosis, Cryptococcosis)
      3. Lyme Disease
      4. Rocky Mountain Spotted Fever (and other Rickettsia infection)
      5. Measles
      6. Rubella
      7. Tularemia
      8. Brucellosis
      9. Bubonic Plague
      10. Typhoid Fever
      11. Scrub Typhus
      12. African Trypanosomiasis (African Sleeping Sickness)
      13. Chagas' Disease
      14. Kala-azar
      15. Sporotrichosis
  3. Causes: Collagen Vascular Causes of Lymphadenopathy
    1. Common
      1. Systemic Lupus Erythematosus
      2. Rheumatoid Arthritis
      3. Sjogren Syndrome
    2. Less Common
      1. Still's Disease
      2. Dermatomyositis
      3. Sarcoidosis
  4. Causes: Neoplastic Causes of Lymphadenopathy
    1. Hodgkin's Lymphoma
    2. Lymphosarcoma
    3. Histiocytic Medullary Reticulosis
    4. Leukemia
      1. Lymphocytic Leukemia
      2. Myelocytic Leukemia
    5. Metastatic cancer
      1. Melanoma and other skin cancers
      2. Kaposi's Sarcoma
      3. Neuroblastoma
      4. Seminoma
      5. Lung Cancer
      6. Breast Cancer
      7. Prostate Cancer
      8. Renal carcinoma
      9. Head and neck cancers
      10. Gastrointestinal tract cancers
  5. Causes: Miscellaneous Causes of Lymphadenopathy
    1. Common
      1. Serum Sickness
      2. Sarcoidosis
      3. Hyperthyroidism
    2. Less Common
      1. Kawasaki Disease
      2. Amyloidosis
      3. Niemann-Pick Disease
      4. Gaucher's Disease
      5. Beryllioisis
      6. Silicosis
      7. Angiofollicular lymph node hyperplasia (Castleman Disease)
      8. Histiocytosis
      9. Kituchi Lymphadenitis
      10. Kimura Disease
  6. References
    1. Degowin (1987) Diagnostic Exam, Macmillan, p. 467
    2. Dornbland (1992) Adult Ambulatory Care, p. 662-7
    3. Wilson (1991) Harrison's Internal Medicine, p. 354-6
    4. Lee (1999) Wintrobe's Hematology, p. 1826-30
    5. Ferrer (1998) Am Fam Physician 58(6): 1313-2 [PubMed]
    6. Gaddey (2016) Am Fam Physician 94(11): 896-903 [PubMed]
    7. Libman (1987) J Gen Intern Med 2(1):48-58 [PubMed]

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