Hematology and Oncology Book

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Monocyte Count

Aka: Monocyte Count, Monocyte, Macrophage
  1. See Also
    1. Complete Blood Count
  2. Characteristics
    1. Forms in Bone Marrow from Myeloblasts as with other Granulocytes (Basophils, Eosinophils, Neutrophils)
    2. Function: Phagocytizes dead or damaged cells
      1. Monocytes move into tissue and become Macrophages
      2. Transformation to Macrophages controlled by cytokines
      3. Macrophages directly perform the phagocytosis
    3. Monocyte Morphology on Blood Smear
      1. Mononuclear Leukocyte (same class as Lymphocyte)
      2. Slightly larger than a Lymphocyte
      3. Kidney shaped nucleus
  3. Interpretation: Normal
    1. Range: 2-8% of White Blood Cells
  4. Causes: Increased
    1. Infection
      1. Viral Infection
      2. Parasitic Infection
    2. Inflammatory Bowel Disease
    3. Sarcoidosis
    4. Neoplasms
    5. Monocytic Leukemia
    6. Lymphoma
    7. Multiple Myeloma
  5. Causes: Decreased
    1. Aplastic Anemia
    2. Lymphocytic Anemia
    3. Glucocorticoids
  6. Evaluation: Monocytosis (Monocytes >880/mm3)
    1. See Leukocytosis
    2. History and potential causes
      1. Travel and contagious contacts
    3. Diagnostics (consider)
      1. Chest XRay
      2. Specific infection testing (e.g. Monospot, PPD or quantiferon)
      3. Acute phase reactants (ESR, CRP)
  7. References
    1. Saiki in Friedman (1991) Medical Diagnosis, p. 227
    2. Abramson (2000) Am Fam Physician 62(9):2053-60 [PubMed]
    3. Riley (2015) Am Fam Physician 92(11):1004-11 [PubMed]

macrophage (C0024432)

Definition (CHV) a kind of white blood cell
Definition (CHV) a kind of white blood cell
Definition (MSHCZE) Buňka, která je schopna pohlcování (fagocytózy) cizorodého materiálu včetně mikroorganismů. Plní i další významné úlohy v imunitě (produkce cytokinů a prezentace antigenů). Vzniká z bílé krvinky (monocytu). Podobného původu jsou i další buňky v organismu, např. histiocyty, Kupfferovy buňky, osteoklasty, mikroglie. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI_NCI-GLOSS) A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.
Definition (CSP) mononuclear phagocytes found in tissue.
Definition (MSH) The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Concepts Cell (T025)
MSH D008264
SnomedCT 58986001
HL7 MAC
LNC LP14314-6, MTHU016340
English Macrophages, Monocytes / Macrophages / APC, macrophages, Macrophage, Macrophage (cell), macrophage, Bone Marrow Derived Macrophages, Bone Marrow-Derived Macrophages, Bone Marrow-Derived Macrophage, Macrophage, Bone Marrow-Derived, Macrophage, Monocyte-Derived, Macrophages, Bone Marrow-Derived, Macrophages, Monocyte Derived, Macrophages, Monocyte-Derived, Monocyte Derived Macrophages, Monocyte-Derived Macrophages, Monocyte-Derived Macrophage
French MDM (Macrophage Dérivé de Monocyte), Macrophages, Macrophages dérivés de monocytes, Macrophage, Macrophages dérivés de la moelle osseuse
Swedish Makrofager
Czech makrofágy
Finnish Makrofagit
German Knochenmark-generierte Makrophagen, Makrophagen, Monozyten-generierte, Makrophage, Monozyten-generierte Makrophagen, Makrophagen
Russian MAKROFAGI, GISTIOTSIT-MAKROFAG, GISTOFAGOTSIT, ГИСТИОЦИТ-МАКРОФАГ, ГИСТОФАГОЦИТ, МАКРОФАГИ
Italian Macrofago, Macrofagi derivati dai monociti, Macrofagi derivati dal midollo osseo, Macrofagi
Croatian MAKROFAGI
Latvian Makrofāgi
Polish Makrofagi
Japanese マクロファージ, 大食球, 大食細胞(ダイショクサイボウ), 大食細胞
Norwegian Makrofager, Makrofag, Makrofager som stammer fra beinmarg, Makrofager som stammer fra monocytter, Makrofager som stammer fra benmarg
Spanish macrófago (célula), macrófago, Macrófagos, Macrófagos Derivados de Monocitos, Macrófagos Derivados de la Médula Ósea
Dutch Macrofaag, Macrofagen
Portuguese Macrófagos, Macrófagos Derivados da Medula Óssea, Macrófagos Derivados de Monócitos
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Monocytes (C0026473)

Definition (MSHCZE) Druh bílé krvinky leukocytu, ze skupiny agranulocytů, mononukleárů. Velikost je 12–20 m, má nesegmentované jádro ledvinovitého tvaru, bazofilní cytoplasmu s četnými granuly a enzymy. (cit. Velký lékařský slovník online, 2013 http://lekarske.slovniky.cz/ )
Definition (NCI) Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Definition (NCI_NCI-GLOSS) A type of immune cell that is made in the bone marrow and travels through the blood to tissues in the body where it becomes a macrophage. Macrophages surround and kill microorganisms, ingest foreign material, remove dead cells, and boost immune responses. A monocyte is a type of white blood cell and a type of phagocyte.
Definition (MSH) Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Definition (CSP) large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood and tissues where they develop into macrophages; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Concepts Cell (T025)
MSH D009000
SnomedCT 55918008
LNC LP14313-8, LP32104-9, MTHU012776
English monocytes, Blood monocytes, Monocytes, blood monocytes, monocytic, monocyte, Monocyte, Monocyte (cell), Monocyte, NOS
Dutch bloed monocyten, monocyten, Monocyt, Monocyten
French Monocytes sanguins, Monocyte, Monocytes
German Monozyten im Blut, Monozyten
Italian Monociti ematici, Monocita, Monociti
Portuguese Monócitos no sangue, Monócitos
Spanish Monocitos en sangre, monocito (célula), monocito, Monocitos
Japanese 血中単球, ケッチュウタンキュウ, タンキュウ, 単球
Swedish Monocyter
Czech monocyty, Monocyty v krvi, Monocyty
Finnish Monosyytit
Russian MONOTSITY, МОНОЦИТЫ
Croatian MONOCITI
Latvian Monocīti
Polish Monocyty
Hungarian Monocita vérszint, Monociták
Norwegian Monocytt, Monocytter
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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