Hematology and Oncology Book

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Hand Foot Syndrome in Sickle Cell Anemia

Aka: Hand Foot Syndrome in Sickle Cell Anemia, Dactylitis in Sickle Cell Anemia
  1. See Also
    1. Sickle Cell Anemia
  2. Epidemiology
    1. Often the first vaso-Occlusion crisis finding in young children
    2. Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years
    3. Rare over age 4 years old
  3. Pathophysiology
    1. Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease
    2. Occurs in Sickle Cell Anemia with vaso-Occlusion
    3. Caused by infarction of Bone Marrow
      1. Metacarpal or Metatarsal Bones and phalanges
  4. Symptoms
    1. Painful swelling and tenderness of either the hand or foot
    2. Digits may appear mildly erythematous
  5. Signs
    1. Low grade fever (variably present)
  6. Differential Diagnosis
    1. Osteomyelitis (Salmonella)
  7. Course
    1. Resolves spontaneously within 1 week
  8. References
    1. Welsh and Welsh (2016) Crit Dec Emerg Med 30(11): 15-23

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