Human Immunodeficiency Virus Book

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Integrase Strand Transfer Inhibitor

Aka: Integrase Strand Transfer Inhibitor, Raltegravir, Isentress, InSTI, RAL
  1. See Also
    1. Anti-Retroviral Therapy
  2. Class
    1. Anti-retroviral agent
    2. Integrase Strand Transfer Inhibitor
  3. Mechanism
    1. Integrase Strand Transfer Inhibitor prevents viral DNA from integrating into host DNA
      1. Blocks the integrase enzyme
  4. Indications
    1. Anti-retroviral naive patients
    2. Anti-retroviral experienced patients
  5. Dosing
    1. One 400 mg tablet orally twice daily
  6. Efficacy
    1. Drug resistance is common
  7. Adverse Effects
    1. Diarrhea
    2. Nausea
    3. Headache
    4. Serum Creatinine phosphokinase (CPK) increases
    5. Myopathy
    6. Rhabdomyolysis
    7. Insomnia
  8. Drug Interactions
    1. Minimal
  9. References
    1. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
    2. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]
Medication Costs
isentress (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing)
ISENTRESS 400 MG TABLET $22.34 each
ral (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
RALOXIFENE HCL 60 MG TABLET Generic $1.24 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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