Gynecology Book

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Tamoxifen

Aka: Tamoxifen
  1. See Also
    1. Selective Estrogen Receptor Modulator
  2. Indications
    1. Breast Cancer in post-menopausal women
      1. Estrogen Receptor positive
    2. Breast Cancer Prevention in pre-Menopause or post-Menopause with Breast Cancer risk >1.66% in 5 years and age over 35 years old
      1. Higher efficacy than Raloxifene for breast Cancer Prevention, but also higher Venous Thromboembolism and Endometrial Cancer Risks
      2. Unlike Tamoxifen, Raloxifene is not approved for pre-menopausal breast Cancer Prevention
  3. Contraindications
    1. Venous Thromboembolism history
    2. Perioperative period
    3. Prolonged immobilization
    4. History of Cerebrovascular Accident (CVA) or Transient Ischemic Attack (TIA)
  4. Efficacy
    1. Estrogen Receptor Positive Breast Cancer
      1. Reduces Breast Cancer recurrence (29%)
      2. Reduces mortality from Breast Cancer (20%)
    2. Reference
      1. (1992) Lancet 339:1-15, 71-85 [PubMed]
  5. Course: Following Breast Cancer Management
    1. Original recommendations were for 5 year course following Breast Cancer Management
    2. As of 2013, ten year course is recommended following Breast Cancer Diagnosis
      1. One additional Breast Cancer recurrence prevented for every 27 women who extend their Tamoxifen course from 5 to 10 years
      2. Benefits still outweigh risks of Endometrial Cancer and Venous Thromboembolism
      3. Davies (2012) Lancet 10.1016/S0140-6736(12)61963-1
  6. Benefits
    1. Anti-Estrogen
      1. Reduces Breast Cancer recurrence rate
    2. Preserves Bone Mineral Density
      1. Only applies to post-menopausal patients
      2. Bone Mineral Density decreases if premenopausal
    3. Lowers Total Cholesterol and LDL Cholesterol
      1. Only applies to post-menopausal patients
      2. No effect on lipids if premenopausal
  7. Dosing
    1. Breast Cancer Prevention: 20 mg daily for 5 years
  8. Adverse Effects
    1. Thromboembolism
      1. Tamoxifen significantly increases risk
      2. Associated with 4 cases per 1000 women on Tamoxifen for 5 years
    2. Endometrial Cancer (risks apply to postmenopausal women)
      1. Markedly increased risk if used more than 5 years
      2. Associated with 4 cases per 1000 women on Tamoxifen for 5 years
      3. Relative Risk for 2 to 5 years of use: 2.0
      4. Relative Risk for 5 or more years of use: 6.9
    3. Hot Flashes
      1. See Hot Flashes for management
      2. Avoid symptomatic management with agents contraindicated following Breast Cancer
        1. Avoid Estrogen and Phytoestrogens
        2. Avoid Paroxetine and Fluoxetine (see below)
    4. Cataracts
      1. Eye Exam every 1-2 years
  9. Drug Interactions
    1. CYP2D6 Inhibitors (e.g. Paroxetine, Fluoxetine, Bupropion)
      1. May decrease Tamoxifen efficacy (avoid these CYP2D6 inhibitors in Breast Cancer patients)
  10. References
    1. (2002) Lancet 360:817-24 [PubMed]
    2. Bergman (2000) Lancet 356:881-7 [PubMed]
Medication Costs
tamoxifen (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
TAMOXIFEN 10 MG TABLET Generic $0.27 each
TAMOXIFEN 20 MG TABLET Generic $0.53 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Tamoxifen (C0039286)

Definition (CHV) syntactic hormone used in breast cancer treatment
Definition (NCI) An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.
Definition (NCI_NCI-GLOSS) A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen.
Definition (CSP) selective estrogen receptor modulator; it is agonist for bone tissue and cholesterol metabolism but antagonist in mammary and uterine tissues.
Definition (MSH) One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013629
SnomedCT 373345002, 75959001
LNC LP18484-3, MTHU003102, LA14344-8
English tamoxifen, Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-, (Z)-2-[4(1,2-diphenyl-1-butenyl)-phenoxyl]-N,N-dimethylethanamine, Tamoxifen, 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene, tamoxifen (medication), Tamoxifen [Chemical/Ingredient], TAMOXIFEN, Tamoxifen (product), Tamoxifen (substance), TMX, TAM
Swedish Tamoxifen
Czech tamoxifen
Finnish Tamoksifeeni
Russian TAMOKSIFEN, ICI 46474, ТАМОКСИФЕН
Japanese タモキシフェン
Polish Tamoksyfen
Spanish tamoxifeno (producto), tamoxifeno (sustancia), tamoxifeno, Tamoxifeno
French Tamoxifène
German Tamoxifen
Italian Tamoxifene
Portuguese Tamoxifeno
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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