Gynecology Book

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Progestin Estrogenic Activity

Aka: Progestin Estrogenic Activity, Estrogenic Activity
  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. General
    1. Most Progestins have some anti-Estrogen activity
    2. Several Progestins have weak Estrogen effect
  3. Characteristics
    1. Conditions associated with High Estrogenic Activity
      1. Breast tenderness or engorgement
      2. Headaches
      3. Moodiness
      4. Weight Gain
      5. Heavy Menses
      6. Dysmenorrhea
    2. Conditions associated with Low Estrogenic Activity
      1. Break-through bleeding in first 9 days of cycle
      2. Break-through bleeding throughout month
      3. Menses too light
  4. Progestins with significant Estrogenic Activity
    1. Estrogen activity based on Ethinyl Estradiol ug/day
    2. Ethinyl estadiol (100): High reference
    3. Norethynodrel (8.3): No anti-Estrogen effect
    4. Ethynodiol Diacetate (3.4)
    5. Norethindrone (0.25): Low reference
  5. Oral Contraceptive Estrogenic Activity (low to high)
    1. Estrogen activity based on Ethinyl Estradiol ug/day
    2. Loestrin 1.5/30 (Norethindrone Acetate): 14
    3. Estrostep (Norethindrone Acetate): 16
    4. Alesse (Levonorgestrel): 17
    5. Loestrin 1/20 (Norethindrone Acetate): 19
    6. Demulen 1/35 (Ethynodiol Diacetate): 19
    7. Nordette (Levonorgestrel): 25
    8. Lo-Ovral (Norgestrel): 25
    9. Triphasil (Levonorgestrel): 28
    10. Ortho-Cept or Desogen (Desogestrel): 30
    11. Ortho-Cyclen (Norgestimate): 35
    12. Ortho Tri-Cyclen (Norgestimate): 35
    13. Ortho-Novum 1/35 (Norethindrone): 38
    14. Modicon (Norethindrone): 42
    15. Ortho-Novum 777 (Norethindrone): 48
  6. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
    2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
    3. Dickey (1998) Managing Contraceptive Pill Patients

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