Gynecology Book

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Progestin Endometrial Activity

Aka: Progestin Endometrial Activity, Endometrial Activity
  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. General
    1. Ability to prevent spotting or breakthrough bleeding
    2. Dependent on Estrogen-Progestin ratio
    3. Bleeding may be due to:
      1. Estrogen insufficiency
      2. Progesterone insufficiency
  3. Progestins with least potent Endometrial Activity
    1. Amount to suppress bleeding for 20 days in 50% women
    2. Gestodene (12.6)
    3. Desogestrel (8.7)
    4. Levonorgestrel (5.1)
    5. dl-Norgestrel (2.6)
  4. Progestins with most Endometrial Activity
    1. Amount to suppress bleeding for 20 days in 50% women
    2. Norethynodrel (0): Low limit reference
    3. Norethindrone Acetate (0.4)
    4. Ethynodiol Diacetate (0.4)
    5. Norethindrone (1.0)
  5. Oral Contraceptives with least Endometrial Activity
    1. Least suppression of bleeding
    2. Progestin-Only (Mini-Pill)
    3. Demulen 1/35
    4. Loestrin
    5. Tri-Norinyl
  6. Oral Contraceptives with most Endometrial Activity
    1. Greatest suppression of bleeding
    2. Ovral
    3. Lo-Ovral
    4. Ortho Novum
    5. Ovcon
    6. Norlestrin
    7. Demulen 50
  7. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
    2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
    3. Dickey (1998) Managing Contraceptive Pill Patients

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