Gynecology Book

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Progestin Androgenic Activity

Aka: Progestin Androgenic Activity, Androgenic Activity
  1. See Also
    1. See Adjunctive Acne Vulgaris Management (low androgen)
    2. Oral Contraceptive
    3. Progestin
  2. General
    1. Unbound testosterone increases with androgenicity
  3. Characteristics
    1. Conditions associated with high Androgenic Activity
      1. Acne Vulgaris
      2. Hirsutism
      3. Polycystic Ovary Syndrome (PCOS)
      4. Obesity (or weight gain)
      5. Nervousness
      6. Lowered HDL-2
    2. Conditions associated with low Androgenic Activity
      1. Decreased libido
  4. Progestins with most potent Androgenic Activity
    1. Methyltestosterone (50): Upper limit reference
    2. Gestodene (8.6)
    3. Levonorgestrel (8.3)
    4. dl-Norgestrel (4.2)
    5. Desogestrel (3.4)
  5. Progestins with least Androgenic Activity
    1. Pregnane Progestin (0)
    2. Norethynodrel (0)
    3. Ethynodiol Diacetate (0.6)
    4. Norethindrone (1.0): Lower limit reference
  6. Oral Contraceptive Androgenic Activity (low to high)
    1. Andogen activity based on Methytestosterone mg/28 days
    2. Ortho Tri-Cyclen (Norgestimate): 0.15
    3. Ortho-Cept or Desogen (Desogestrel): 0.17
    4. Modicon (Norethindrone): 0.17
    5. Ortho-Cyclen (Norgestimate): 0.18
    6. Demulen 1/35 (Ethynodiol Diacetate): 0.21
    7. Ortho-Novum 777 (Norethindrone): 0.25
    8. Triphasil (Levonorgestrel): 0.29
    9. Alesse (Levonorgestrel): 0.31
    10. Ortho-Novum 1/35 (Norethindrone): 0.34
    11. Nordette (Levonorgestrel): 0.46
    12. Lo-Ovral (Norgestrel): 0.46
    13. Estrostep (Norethindrone Acetate): 0.53
    14. Loestrin 1/20 (Norethindrone Acetate): 0.53
    15. Loestrin 1.5/30 (Norethindrone Acetate): 0.80
  7. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
    2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
    3. Dickey (1998) Managing Contraceptive Pill Patients

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