Gynecology Book

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Progestin Activity

Aka: Progestin Activity, Progestational Activity, Progesterone Potency
  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. General
    1. Depends on Estrogen stimulating Progestin receptors
  3. Characteristics
    1. Conditions associated with High Progestin Activity
      1. Increased Appetite
      2. Major Depression
    2. Conditions associated with Low Progestin Activity
      1. Mid-cycle spotting (days 10-21)
      2. Heavy Menses
      3. Dysmenorrhea
  4. Preparations: Progestins with most potent Progestational Activity
    1. Progestin Activity based on Norethindrone mg/day
    2. Gestodene (12.6)
    3. Desogestrel (9.0)
    4. Levonorgestrel (5.3)
    5. dl-Norgestrel (2.6)
    6. Norethindrone (1.0) - Low reference
  5. Preparations: Oral Contraceptive Progestin Activity (low to high)
    1. Progestin Activity based on Norethindrone mg/day
    2. Ortho-Cyclen (Norgestimate): 0.3
    3. Ortho Tri-Cyclen (Norgestimate): 0.3
    4. Alesse (Levonorgestrel): 0.5
    5. Triphasil (Levonorgestrel): 0.5
    6. Modicon (Norethindrone): 0.5
    7. Nordette (Levonorgestrel): 0.8
    8. Lo-Ovral (Norgestrel): 0.8
    9. Ortho-Novum 777 (Norethindrone): 0.8
    10. Ortho-Novum 1/35 (Norethindrone): 1.0
    11. Ortho-Cept or Desogen (Desogestrel): 1.0
    12. Estrostep (Norethindrone Acetate): 1.2
    13. Loestrin 1/20 (Norethindrone Acetate): 1.4
    14. Demulen 1/35 (Ethynodiol Diacetate): 1.4
    15. Loestrin 1.5/30 (Norethindrone Acetate): 1.7
  6. References
    1. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
    2. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
    3. Dickey (1998) Managing Contraceptive Pill Patients

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