Gynecology Book

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Oral Contraceptive Drug Interaction

Aka: Oral Contraceptive Drug Interaction
  1. See Also
    1. Oral Contraceptive
    2. Oral Contraceptive Side Effect Management
  2. Drug Interactions: Drugs decreasing Oral Contraceptive efficacy
    1. See Antiepileptic Drug Interactions in Contraception
    2. Enzyme Inducing Drugs (e.g. Rifampin, Rifapentine, rifabutin) signicantly reduce OCP efficacy
      1. Use backup Contraception
      2. Barrier methods or Depo Provera if <2 months of enzyme inducing drug
      3. Depo Provera or Progesterone IUD if >2 months of enzyme inducing drug
      4. (2015) Presc Lett 22(6): 31-2
    3. Other medications reduce OCP efficacy less
      1. Amoxicillin
      2. Ampicillin
      3. Erythromycin
      4. Fluconazole (Diflucan)
      5. Griseofulvin
      6. Itraconazole (Sporanox)
      7. Ketoconazole (Nizoral)
      8. Metronidazole (Flagyl)
      9. Ritonavir
      10. St. John's Wort (results in breakthrough bleeding)
      11. Tetracycline
      12. Troglitazone (Rezulin)
  3. Drug Interactions: Drugs with decreased efficacy when taken with OCP
    1. Clofibrate (Atromid-S)
    2. Lorazepam (Ativan)
    3. Oxazepam (Serax)
    4. Salicylates
    5. Temazepam (Restoril)
  4. Drug Interactions: Drugs potentiated by Oral Contraceptives
    1. Benzodiazepines
      1. Alprazolam (Xanax)
      2. Chlordiazepoxide (Librium)
      3. Diazepam (Valium)
      4. Flurazepam (Dalmane)
      5. Triazolam (Halcion)
    2. Beta Blockers
    3. Caffeine
    4. Corticosteroids
      1. Hydrocortisone
      2. Methylprednisolone
      3. Prednisolone
      4. Prednisone
    5. Theophylline (monitor levels)
    6. Tricyclic Antidepressants (monitor levels)
  5. References
    1. Bolt (1994) Environ Health Perspect 102(suppl 9):35-8 [PubMed]
    2. Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
    3. Fazio (1991) South Med J 84:997-1002 [PubMed]
    4. Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
    5. Schwartz (1999) J Gend Specif Med 2(6):26-9 [PubMed]
    6. Tatro (1996) Drug Newsletter 15:66-9
    7. Dickey (1994) Managing Contraceptive Pill Patients

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