Gynecology Book

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Danazol

Aka: Danazol
  1. Indications
    1. Endometriosis
  2. Pathophysiology
    1. Synthetic isoxazol derivative of ethisterone
    2. Inhibits gonadotropic secretion
    3. Prevents Menstrual Bleeding
    4. Mildly androgenic
  3. Dosing
    1. Danazol 400-600 mg qd
  4. Efficacy
    1. Expensive ($100/month)
    2. Same rate of pregnancy as with Provera or Surgery
  5. Adverse Effects: Androgenic effects
    1. Acne Vulgaris
    2. Flushes
    3. Sweats
    4. Edema
    5. Libido changes
Medication Costs
danazol (on 12/21/2016 at Medicaid.Gov Pharmacy Drug pricing)
DANAZOL 200 MG CAPSULE Generic $5.22 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Danazol (C0010961)

Definition (NCI) A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)
Definition (NCI_NCI-GLOSS) A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer.
Definition (MSH) A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Definition (PDQ) A synthetic androgen derived from ethinyl testosterone. Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39204&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C414" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110)
MSH D003613
SnomedCT 87881000, 126124009
LNC LP172589-6, MTHU046384
English Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17alpha)-, danazol, 17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole, 1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol, (17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol, DAN, danazol (medication), Danazol [Chemical/Ingredient], DANAZOL, (17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, Danazol preparation, Danazol product, Danazol (substance), Danazol preparation (product), Danazol preparation (substance), Danazol
Swedish Danazol
Czech danazol
Finnish Danatsoli
Russian DANAZOL, ДАНАЗОЛ
Japanese ダナゾール
Spanish danazol (producto), preparado con danazol (producto), preparado con danazol, danazol (sustancia), danazol, preparado de danazol (producto), preparado de danazol (sustancia), preparado de danazol, Danazol
Polish Danazol
French Danazol
German Danazol
Italian Danazolo
Portuguese Danazol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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