Gynecology Book

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HAIR-AN Syndrome

Aka: HAIR-AN Syndrome
  1. See Also
    1. Insulin Resistance Syndrome
  2. Definition: Hair-AN Acronym
    1. Hyperandrogenism (HA)
    2. Insulin Resistance (IR)
    3. Acanthosis Nigricans (AN)
  3. Pathophysiology
    1. Primary abnormality
      1. Insulin Resistance causes increased Insulin
    2. Secondary abnormality
      1. Excess androgen secretion from ovaries
  4. Associated Conditions
    1. Hashimoto's Thyroiditis
    2. Grave's Disease
  5. Differential Diagnosis
    1. See Hyperandrogenism
    2. See Hirsutism
    3. See Acanthosis Nigricans
    4. Diabetes Mellitus
    5. Acromegaly
  6. Labs
    1. General lab testing
      1. Complete Blood Count (CBC)
      2. Thyroid Stimulating Hormone (TSH)
      3. Serum Prolactin
      4. Serum electrolytes (Chem7)
    2. Labs associated with Insulin Resistance
      1. Fasting Serum Glucose
      2. Consider Glucose Tolerance Test
    3. Labs associated with Androgen Excess
      1. See Hyperandrogenism
  7. Management
    1. General Measures
      1. Weight loss
      2. See Hirsutism
    2. Gonadotropin suppression
      1. Oral Contraceptives (low Androgenic Activity)
        1. Desogestrel (Desogen)
        2. Norgestimate (Ortho-Cyclen)
      2. Anti-androgens
        1. Spironolactone (Aldactone) 50 to 100 mg po bid
        2. Flutamide (Eulexin)
          1. Risk of hepatotoxicity
        3. Finasteride (Proscar) 5 mg per day
    3. Insulin Resistance Modifier
      1. Glucophage (Metformin) 500 - 850 mg PO qd to bid
  8. References
    1. Barbieri (1994) J Reprod Med 39:327-36 [PubMed]
    2. Elmer (2001) Am Fam Physician 63(12): 2385-90 [PubMed]

HAIR-AN syndrome (C1963745)

Concepts Disease or Syndrome (T047)
MSH C537629
Spanish Síndrome HAIR-AN
French Syndrome HAIR-AN
Dutch HAIR-AN-syndroom
Portuguese Síndrome de HAIR-AN
German HAIR-AN Syndrom
Italian Sindrome HAIR-AN
Japanese HAIR−AN症候群, HAIRANショウコウグン
Czech Syndrom HAIR-AN
English HAIR-AN syndrome, Hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN), Hyperandrogenic, insulin-resistant acanthosis nigricans syndrome
Hungarian HAIR-AN syndroma
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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