Geriatric Medicine Book

Adverse Drug Reaction

  • Drug-Drug Interactions in the Elderly

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Drug-Drug Interactions in the Elderly

Aka: Drug-Drug Interactions in the Elderly
  1. See Also
    1. Polypharmacy
    2. Medications to Avoid in Older Adults (STOPP, Beers' Criteria)
    3. Medication Causes of Delirium in the Elderly
  2. Adverse Effect: Increased Drug effect (common)
    1. Azathioprine (Imuran, Bone Marrow suppression risk)
      1. Allopurinol
    2. Benzodiazepines and other sedative hypnotics (Sedation risk)
      1. Alcohol
    3. Digoxin (Digoxin Toxicity risk)
      1. Diuretics
      2. Quinidine
    4. Methotrexate (Bone Marrow suppression risk)
      1. Aspirin
      2. Sulfisoxazole
    5. Phenytoin (Ataxia and Sedation risk)
      1. Chloramphenicol
      2. Isoniazid
      3. Phenylbutazone
    6. Propranolol (Bradycardia risk)
      1. Cimetidine (Tagamet)
    7. Sulfonylureas (Hypoglycemia risk)
      1. Chloramphenicol
      2. Phenylbutazone
      3. Warfarin
    8. Warfarin (Bleeding risk)
      1. Aspirin
      2. Metronidazole
      3. Phenylbutazone
  3. Adverse Effect: Decreased Drug effect (common)
    1. Metformin
      1. Risperidone
    2. Pioglitazone (Actos)
      1. Olanzapine (Zyprexa)
    3. Prednisone
      1. Barbiturates
    4. Quinidine
      1. Barbiturates
      2. Rifampin
    5. Tetracycline
      1. Antacids
    6. Warfarin
      1. Barbiturates
      2. Rifampin
  4. References
    1. Bressler (2003) Mayo Clin Proc 78:1564-77 [PubMed]

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