Gastroenterology Book

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Prochlorperazine

Aka: Prochlorperazine, Compazine
  1. Indications
    1. Nausea or Vomiting
    2. Migraine Headache
    3. Motion Sickness
    4. Vertigo
    5. Hiccups
  2. Mechanism
    1. Phenothiazine Antiemetic
    2. Dopamine 2 Antagonist
  3. Adverse effects
    1. Orthostatic Hypotension
    2. Extrapyramidal Reaction
      1. Precaution
        1. Reactions may be delayed up to 2 weeks after dose
      2. Reactions
        1. Akathisia (25-60% after single dose)
        2. Dystonic Reaction (4% after a single dose)
        3. Olsen (2000) Am J Emerg Med 18(5): 609-11 +PMID:10999579 [PubMed]
        4. Drotts (1999) Ann Emerg Med 34(4 Pt 1): 469-75 [PubMed]
      3. Concurrent Diphenhydramine (Benadryl) prevents Akathisia (NNT 5, ARR 22%)
        1. Diphenhydramine (Benadryl) 50 mg IV (adults) was the dose used in study
        2. Vinson (2001) Ann Emerg Med 37(2):125-31 +PMID:11174228 [PubMed]
  4. Dosing
    1. Adults
      1. Compazine 5-10 mg PO/IV/IM q6-8 hours
      2. Compazine 25 mg PR q12 hours
      3. Sustained release Compazine 15 mg PO qam or 10 mg bid
    2. Children (over age 2 years or >10 kg)
      1. Compazine 0.1 mg/kg/dose PO/PR q6-8 hours
      2. Compazine 0.1 to 0.15 mg IM q6-8 hours
  5. Precautions
    1. IV dosing must be administered over 2 minutes or more
    2. Lowers Seizure threshold
  6. Efficacy
    1. Better Antiemetic than Phenergan in ER patients
      1. Ernst (2000) Ann Emerg Med 36(2): 89-94 [PubMed]
  7. References
    1. Johnson (1993) Harriet Lane, Mosby, p. 521
    2. (2002) Tarascon Pocket Pharmacopoeia, p. 67
    3. Olsen (2000) Am J Emerg Med 18(5):609-11 [PubMed]
    4. Vinson (2001) Ann Emerg Med 37(2):125-31 [PubMed]
Medication Costs
Prochlorperazine (on 6/18/2017 at Walmart.com)
Prochlorperazine 10mg #30 tablets for $4.00 $0.13 each
Prochlorperazine 10mg #90 tablets for $10.00 $0.11 each
prochlorperazine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
PROCHLORPERAZINE 10 MG TAB Generic $0.09 each
PROCHLORPERAZINE 25 MG SUPP Generic $7.40 each
PROCHLORPERAZINE 5 MG TABLET Generic $0.07 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Prochlorperazine (C0033229)

Definition (NCI) A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI04)
Definition (NCI_NCI-GLOSS) A drug used to prevent or reduce nausea and vomiting. It belongs to the family of drugs called antiemetics.
Definition (MSH) A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Definition (CSP) phenothiazine derivative used chiefly as an antiemetic.
Definition (PDQ) A synthetic propylpiperazine derivative of phenothiazine with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39564&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39564&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C774" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011346
SnomedCT 322128008, 321493000, 372853006, 79129001
LNC LP102316-9, MTHU036745
English Prochlorperazine, 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, Prochlorperazine [antipsych], Prochlorperazine [antipsych] [see dhe..], Prochlorperazine [nausea], 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine, prochlorperazine (medication), PROCHLORPERAZINE, Prochlorperazine [Chemical/Ingredient], Prochlorperazine [nausea] (product), Prochlorperazine [antipsych] [see dhe..] (product), prochlorperazine, Prochlorperazine (product), Prochlorperazine (substance), PCPZ, Prochlorperazine [antipsych] [see dhe..] (substance), Prochlorperazine [nausea] (substance)
Swedish Proklorperazin
Czech prochlorperazin
Finnish Proklooriperatsiini
Russian PROKHLORPERAZIN, ПРОХЛОРПЕРАЗИН
Japanese プロクロルペラジン
Spanish proclorperacina (producto), proclorperazina, proclorperazina (producto), proclorperazina [antipsicótico] [véase dhe...], proclorperazina [náuseas], proclorperazina [antipsicótico] [véase dhe...] (producto), proclorperazina [náuseas] (producto), proclorperacina (sustancia), proclorperacina, Proclorperazina
Polish Prochlorperazyna
French Prochlorpérazine
German Prochlorperazin
Italian Procloroperazina
Portuguese Proclorperazina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Compazine (C0701017)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D011346
SnomedCT 79129001
Spanish compazina, compacina
English compazine, Compazine
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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