Gastroenterology Book

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Methylnatrexone

Aka: Methylnatrexone, Relistor
  1. See Also
    1. Opioid Adverse Effect Management
    2. Bowel Regimen in Chronic Narcotic Use
  2. Indications
    1. Severe refractory Constipation due to Cancer Pain Opioid
  3. Mechanism
    1. Mu-Opioid receptor mediated bowel paralysis
  4. Dosing
    1. Methylnaltrexone 5 mg or 0.15 mg/kg SQ
  5. Advantages
    1. Does not cross blood-brain barrier
  6. Efficacy: Terminally ill patients
    1. Bowel Movement occurs within 4 hours of dose in 48% of patients (15% wiith Placebo)
    2. Median time to Bowel Movement is 45 minutes (>6 hours for Placebo)
  7. References
    1. Portenoy (2008) J Pain Symptom Manage 35(5): 458-68 [PubMed]
    2. Thomas (2008) N Engl J Med 358(22): 2332-43 [PubMed]
Medication Costs
relistor (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
RELISTOR 12 MG/0.6 ML SYRINGE $159.82 per ml
RELISTOR 150 MG TABLET $15.90 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

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