Gastroenterology Book

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Cancer Antigen 19-9

Aka: Cancer Antigen 19-9, CA 19-9
  1. Pathophysiology
    1. Cancer Antigen 19-9 is expressed in pancreatic disease and hepatobiliary disease
  2. Indications
    1. Pancreatic ductal adenocarcinoma
      1. Confirms diagnosis
      2. Predicts prognosis as well as recurrence risk
    2. Not indicated for screening in asymptomatic patients
      1. No tumor specific (see efficacy below)
  3. Causes: Increased CA 19-9
    1. Pancreatic Ductal Adenocarcinoma
    2. Chronic Pancreatitis
    3. Chronic inflammatory states
  4. Efficacy: Pancreatic Ductal Adenocarcinoma
    1. Test Sensitivity: 50-75%
    2. Test Specificity: 80-85%
  5. References
    1. Safi (1987) Pancreas 2(4): 398-403 [PubMed]

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