Endocrinology Book


Benign Premature Adrenarche

Aka: Benign Premature Adrenarche, Premature Adrenarche
  1. Pathophysiology
    1. Benign self-limited cause of Precocious Puberty
  2. Epidemiology
    1. Onset before age 6 years
  3. Signs
    1. Early secondary sexual characteristics in children
      1. Early pubic hair and axillary hair development
      2. Increased sebaceous activity
      3. Adult-type body odor
    2. No Sexual Development
    3. Normal growth pattern
  4. Radiology
    1. Bone Age consistent Chronological age
    2. Other imaging studies normal
  5. Labs
    1. Slight increase in Serum DHEA level
    2. Other adrenal steroid hormones normal
    3. Sex hormone levels normal
    4. ACTH Stimulation Test normal
      1. No Congenital Adrenal Hyperplasia
    5. GnRH Stimulation Test normal
      1. Consistent with prepubertal pattern
  6. Management
    1. Reassurance

Premature adrenarche (C0342546)

Definition (NCI) Premature onset of adrenal androgen-mediated secondary sexual characteristics.(NICHD)
Concepts Disease or Syndrome (T047)
ICD10 E27.0
SnomedCT 190521009, 190516006, 103021001
Dutch vroegtijdige adrenarche, adrenarche; prematuur, prematuur; adrenarche
French Adrénarche précoce
German vorzeitige Adrenarche
Italian Adrenarca precoce
Portuguese Adrenarca prematura
Spanish Adrenarquia prematura, adrenarca prematura (hallazgo), adrenarca prematura
Japanese 早発性副腎皮質機能障害, ソウハツセイフクジンヒシツキノウショウガイ
English precocious adrenarche (diagnosis), precocious adrenarche, premature adrenarche, Premature adrenarche (disorder), Premature Adrenarche, Premature adrenarche, Premature adrenarche (finding), adrenarche; premature, premature; adrenarche
Czech Předčasná adrenarché
Hungarian Korai adrenarche
Derived from the NIH UMLS (Unified Medical Language System)

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