Endocrinology Book

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Human Growth Hormone

Aka: Human Growth Hormone, Growth Hormone, hGH
  1. Indications
    1. Medical Uses
      1. Used to enhance growth in Short Stature
    2. Illicit uses
      1. Ergogenic Aid used by athletes
      2. Similar effect as with Anabolic Steroids
        1. Difficult to detect
        2. Expensive (>$1000/month)
  2. Mechanism
    1. Liver converts GH to Insulin-like growth factor (IGF-1)
    2. Precursor to testosterone
  3. Source
    1. Initially derived from cadavers in 1950's
      1. Transmitted Creutzfeldt-Jakob Disease to patients
    2. Now produced by recombinant Genetics
      1. Genentech developed Somatrem (Protropin) in 1990s
  4. Dosing
    1. Available only via injection
  5. Adverse Effects
    1. Growth-hormone induced Myopathy
      1. Muscles hypertrophy, but are weaker than before
    2. Acromegaly
    3. Diabetes Mellitus
    4. Cardiomyopathy
    5. Congestive Heart Failure
    6. May be related to Leukemia development

Growth Hormone (C0037663)

Definition (NCI_NCI-GLOSS) A protein made by the pituitary gland that helps control body growth and the use of glucose and fat in the body.
Definition (NCI) A peptide hormone secreted by the anterior lobe of the pituitary gland and regulates several physiologic processes, including growth and metabolism.
Definition (MSH) A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D013006
SnomedCT 350365006, 56234005
LNC LP14695-8, MTHU002890
English Growth Hormone, Pituitary, Pituitary Growth Hormone, Somatotropin, GH - Growth hormone, Growth hormone, Somatotrophin, Somatrophic hormone, somatotropin, Growth Hormone, growth hormones, growth hormones (medication), STH, Growth Hormone [Chemical/Ingredient], growth hormone, somatotrophin, pituitary growth hormone, somatotropic hormone, Somatrophic hormone (product), Growth hormone preparation, Growth hormone product, Somatotropin preparation, Somatotropin preparation (product), Somatotropin preparation (substance), Somatrophic hormone (substance), GH, GHN, Growth Hormone 1, Somatotropic Hormone, hGHN, SOMATOTROPIN
Swedish Tillväxthormon
Czech růstový hormon, somatotropin, STH
Finnish Kasvuhormoni
French Somatotrophine, Hormone de croissance, Hormone somatotrope, Somatotropine, GH (Growth hormone), STH (Somatotrophic hormone), Somathormone
Russian ROSTA GORMON GIPOFIZARNYI, SOMATOTROPIN, ROSTA GORMON, GORMONY ROSTA GIPOFIZARNYE REKOMBINANTNYE, ROSTA GORMONY GIPOFIZARNYE REKOMBINANTNYE, GIPOFIZARNYE GORMONY ROSTA REKOMBINANTNYE, GORMON ROSTA GIPOFIZARNYI, SOMATOTROPINY REKOMBINANTNYE, ГИПОФИЗАРНЫЕ ГОРМОНЫ РОСТА РЕКОМБИНАНТНЫЕ, ГОРМОН РОСТА ГИПОФИЗАРНЫЙ, ГОРМОНЫ РОСТА ГИПОФИЗАРНЫЕ РЕКОМБИНАНТНЫЕ, РОСТА ГОРМОН, РОСТА ГОРМОН ГИПОФИЗАРНЫЙ, РОСТА ГОРМОНЫ ГИПОФИЗАРНЫЕ РЕКОМБИНАНТНЫЕ, СОМАТОТРОПИН, СОМАТОТРОПИНЫ РЕКОМБИНАНТНЫЕ
Japanese 下垂体成長ホルモン, 下垂体成長ホルモン-組換え, 組換え下垂体成長ホルモン, 組換え成長ホルモン, 組換え成長ホルモン下垂体, 脳下垂体成長ホルモン-組換え, 成長ホルモン-脳下垂体性, 組換え脳下垂体成長ホルモン, 成長ホルモン下垂体-組換え, ソマトトロピン, 下垂体組替え成長ホルモン, 組換成長ホルモン, 組替えソマトトロピン, ソマトトロピン-組換え, 脳下垂体成長ホルモン, 成長ホルモン-組換え, 組換えソマトトロピン, 遺伝子組換え成長ホルモン, 成長ホルモン
Spanish preparado de somatotrofina (producto), somatotrofina (producto), somatotrofina, preparado de somatotrofina, hormona somatotrófica (producto), hormona somatotrófica, Somatotrofina, hormona somatrófica (sustancia), preparado de STH, preparado de hormona del crecimiento, preparado de somatotrofina (sustancia), preparado de somatotropina, hormona somatrófica (producto), hormona somatrófica, Hormona del Crecimiento, Somatotropina, Hormona Hipofisaria del Crecimiento
Italian Ormone della crescita, Ormone pituitario della crescita, Ormone somatotropo, GH, Somatotropina
Croatian SOMATOTROPIN, HORMON RASTA
Polish Ludzki rekombinowany hormon wzrostu, Somatotropiny rekombinowane, rhGH, Hormon wzrostu, Rekombinowane przysadkowe hormony wzrostu, Rekombinowany hormon wzrostu
Norwegian STH, Somatotropin, Somatotropt hormon, GH, Veksthormon
Portuguese Somatotrofina, Somatotropina, Hormônio do Crescimento, Hormônio Hipofisário do Crescimento
German Hypophysen-Wachstumshormon, STH, Somatotropin, Wachstumshormon, Hypophysen-, Wachstumshormon
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Somatropin (C0169964)

Concepts Pharmacologic Substance (T121) , Hormone (T125) , Amino Acid, Peptide, or Protein (T116)
MSH D019382
SnomedCT 395883003, 325831003, 325892008, 129495007
English Biosynthetic human growth horm, HGH - Growth hormone, Somatropin, somatropin, Somatotrophin, Human growth hormone, GH - Growth hormone, Somatotropic hormone, Growth hormone, SOMATROPIN, Somatropin [2] (product), Somatropin [2], Biosynthetic human growth hormone, Somatropin (product), Somatropin (substance), Somatropin [2] (substance)
Spanish hormona de crecimiento, somatotrofina, hormona somatotrófica, somatropina (2), somatropina (2) (producto), somatropina (producto), somatropina (sustancia), somatropina
Czech somatropin (lidský), lidský růstový hormon, somatotropin (lidský)
Finnish Ihmisen kasvuhormoni
French Somatotropine humaine, Somatropine humaine, Hormone de croissance humaine, hGH (Human Growth Hormone)
Italian Somatotropina (umana), Somatropina (umana), Somatropina, Ormone della crescita umano, hGH (ormone della crescita umano)
Russian GORMON ROSTA CHELOVEKA, ROSTA GORMON METIONILOVYI CHELOVEKA, SOMATOTROPIN CHELOVEKA, SOMATROPIN, ROSTA GORMON CHELOVEKA, METIONILOVYI GORMON ROSTA CHELOVEKA, SOMATREM, ГОРМОН РОСТА ЧЕЛОВЕКА, МЕТИОНИЛОВЫЙ ГОРМОН РОСТА ЧЕЛОВЕКА, РОСТА ГОРМОН МЕТИОНИЛОВЫЙ ЧЕЛОВЕКА, СОМАТОТРОПИН ЧЕЛОВЕКА, СОМАТРЕМ, СОМАТРОПИН
Japanese ソマトトロピン(ヒト), ソマトトロピン-ヒト, ヒト成長ホルモン, ソマトロピン, 成長ホルモン-ヒト
Croatian HORMON RASTA, HUMANI, HUMANI HORMON RASTA
Polish Ludzki hormon wzrostu, Somatropina, HGH, Somatotropina (ludzka)
Norwegian Veksthormon, humant, Humant veksthormon, Somatropin (humant), hGH (human veksthormon), Somatropin
German Humanes Wachstumshormon, Somatotropin (humanes), Somatropin, HGH (Humanes Wachstumshormon), Somatropin (humanes)
Portuguese Somatotropina (Humana), Somatropina (Humana), Hormônio do Crescimento Humano
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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