Dermatology Book

Neutrophil

  • Pyoderma Gangrenosum

http://www.fpnotebook.com/

Pyoderma Gangrenosum

Aka: Pyoderma Gangrenosum, Pathergy
  1. Epidemiology
    1. Rare
  2. Pathophysiology
    1. Neutrophilic dermatosis
      1. Also occurs in Behcet Disease and Sweet Syndrome
      2. Neutrophils release elastase and other enzymes that result in skin breakdown
  3. Symptoms
    1. Painful Pustules and ulcers that form on the legs, buttocks, Abdomen and face in response to minor Skin Trauma
  4. Signs
    1. Lesion characteristics
      1. Initial
        1. Hemorrhagic, red Pustule or painful, tender Nodule
      2. Next
        1. Lesion ulcerates
        2. Ulcer has irregular, raised, undermined border and advances peripherally
        3. Ulcer base with exudate that is pustular and hemorrhagic
        4. Necrotic eschar may form
      3. Next
        1. Ulcer heals with thin, atrophic scar
    2. Distribution (in order of most common to least common)
      1. Legs
      2. Buttocks
      3. Abdomen
      4. Face
    3. Pathergy
      1. See Pathergy Test
      2. Blistering and ulceration in response to minor Trauma
      3. Also seen with Behcet Disease
  5. Associated Conditions
    1. Inflammatory Bowel Disease (e.g. Crohn's Disease, Ulcerative Colitis)
    2. Arthritis
    3. Hematologic Malignancy (e.g. Multiple Myeloma, Leukemia)
    4. Hepatitis
  6. Differential Diagnosis
    1. See Skin Ulcer
  7. References
    1. Fitzpatrick (1992) Color Atlas and Synopsis of Clinical Dermatology
    2. Jhun and DeClerck in Herbert (2015) EM:Rap 15(8): 19-20
    3. Heiner (2015) Ann Emerg Med 66(2):115-8 [PubMed]

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree