Dermatology Book

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Podophyllotoxin

Aka: Podophyllotoxin, Condylox, Podofilox
  1. Indication
    1. Genital Warts (home application)
  2. Contraindications
    1. Not recommended for mucosal lesions
      1. Avoid on perianal, rectal, Urethral, vaginal warts
  3. Background
    1. Purified form of Podophyllotoxin extract
  4. Mechanism
    1. Stops division of infected cells
  5. Preparation
    1. Podofilox (Condylox) 0.5% solution or gel
      1. Apply solution with cotton swab
      2. Apply Gel with finger (easier to apply)
  6. Technique
    1. Cycle application
      1. Apply twice daily for 3 days
      2. Wait 4 days, then restart application cycle
    2. Repeat cycle for up to 4 weekly cycles (maximum 10 cm^2)
  7. Advantages
    1. Less irritating and as effective than Podophyllin
    2. Can use in conjunction with other methods
  8. Precautions
    1. Allow to dry before moving around
    2. Do not wash off
    3. Do not exceed 0.5 ml per day
  9. Efficacy
    1. Works best on moist mucosal skin sites
    2. Does not work on keratinized Epidermis
    3. Similar efficacy to Imiquimod
      1. Complete clearance of Genital Warts in 45-77% with a 4-33% recurrence rate
      2. Buck (2006) Clin Evid (15): 2149-61 [PubMed]
  10. Safety
    1. Pregnancy Category C
Medication Costs
condylox (on 2/22/2017 at Medicaid.Gov Pharmacy Drug pricing)
CONDYLOX 0.5% GEL $150.95 per gram
podofilox (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
PODOFILOX 0.5% TOPICAL SOLN Generic $14.08 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

podofilox (C0032334)

Definition (NCI) A pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04)
Definition (MSH) A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH D011034
SnomedCT 76575003, 415128000, 108931008, 415127005, 7959004
English Podofilox, Podophyllotoxin, Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9alpha))-, PODOFILOX, podofilox (medication), podofilox, Podophyllotoxin [Chemical/Ingredient], podophyllotoxin, Podofilox (substance), Podofilox preparation (product), Podofilox preparation, Podophyllotoxin (substance), Podophyllotoxin product, Podophyllotoxin product (product)
Swedish Podofyllotoxin
Czech podofylotoxin
Finnish Podofyllotoksiini
Russian PODOFILLOTOKSIN, EPIPODOFILLOTOKSIN, ПОДОФИЛЛОТОКСИН, ЭПИПОДОФИЛЛОТОКСИН
Japanese ポドフィロックス, ポドフィロトキシン, エピポドフィロトキシン
Spanish producto con podofilotoxina (producto), podofilotoxina (producto), producto con podofilotoxina, preparación con podofilox (producto), preparación con podofilox, podofilox, preparación con podofilotoxina, podofilox (sustancia), podofilotoxina (sustancia), podofilotoxina, Podofilotoxina
Italian Podofilox, Podofillotossina
Polish Podofilotoksyna
French Podophyllotoxine
German Podophyllotoxin
Portuguese Podofilotoxina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Condylox (C0700937)

Concepts Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109)
MSH D011034
English condylox, Condylox, Oclassen Brand of Podophyllotoxin, Wolff Brand of Podophyllotoxin
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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