Dermatology Book

http://www.fpnotebook.com/

Differin

Aka: Differin, Adapalene, Epiduo
  1. See Also
    1. Acne Vulgaris Pharmacologic Management
  2. Indication
    1. Acne Vulgaris
  3. Mechanism
    1. Comedolytic
    2. Synthetic retinoid analog
  4. Supplied
    1. Adapalene only
      1. Gel 0.1% (Over-the-counter in U.S. as of 2017)
      2. Gel 0.3%
      3. Cream 0.1%
      4. Lotion 0.1%
    2. Combinations
      1. Adapalene/Benzoyl Peroxide 0.1%/0.25% (Epiduo)
  5. Adverse Effects
    1. Same as Tretinoin, but less severe
  6. Safety
    1. Pregnancy Category C
      1. But generally recommended to avoid in pregnancy (esp. first trimester)
  7. Efficacy
    1. As effective as Tretinoin (Retin-A)
    2. Better tolerated than Tretinoin (less irritation)
  8. Disadvantages
    1. More expensive than generic Tretinoin (roughly 5 fold higher price)
  9. Reference
    1. (1997) Med Lett Drugs Ther, 39:19-20 [PubMed]
Medication Costs
differin (on 10/19/2016 at Medicaid.Gov Pharmacy Drug pricing)
DIFFERIN 0.1% CREAM Generic $3.47 per gram
DIFFERIN 0.3% GEL PUMP Generic $4.46 per gram
adapalene (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
ADAPALENE 0.1% CREAM Generic $3.47 per gram
ADAPALENE 0.1% GEL Generic $2.21 per gram
ADAPALENE 0.3% GEL Generic $3.70 per gram
ADAPALENE 0.3% GEL PUMP Generic $4.46 per gram
epiduo (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
EPIDUO 0.1-2.5% GEL PUMP $8.76 per gram
EPIDUO FORTE 0.3-2.5% GEL PUMP $10.19 per gram
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

adapalene (C0165631)

Definition (NCI) A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C063610
SnomedCT 332377001, 391719005, 108903004, 386934008
English 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid, adapalene, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, 6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid, ADAPALENE, retinoids adapalene, adapalene (medication), adapalene [Chemical/Ingredient], Adapalene - chemical, Adapalene - chemical (substance), Adapalene, Adapalene (product), Adapalene (substance)
Spanish adapaleno (producto), adapaleno (sustancia), adapaleno
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Differin (C0593946)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C063610
English Differin, differin, Allphar brand of adapalene, Differine, Galderma brand of adapalene
Sources
Derived from the NIH UMLS (Unified Medical Language System)


adapalene 0.001 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo] (C2586879)

Concepts Clinical Drug (T200)
English Epiduo 0.1%-2.5% Topical Gel, adapalene 0.001 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo], Epiduo (adapalene 0.1 % / benzoyl peroxide 2.5 %) Topical Gel, Epiduo, 0.1%-2.5% topical gel, ADAPALENE 0.1 %WW TOPICAL GEL [EPIDUO], ADAPALENE 0.1 %WW / BENZOYL PEROXIDE 2.5 %WW TOPICAL GEL [EPIDUO], Epiduo (adapalene 1 MG / benzoyl peroxide 25 MG) per GM Topical Gel, ADAPALENE 1 mg in 1 g / BENZOYL PEROXIDE 25 mg in 1 g TOPICAL GEL [EPIDUO], ADAPALENE 1 MILLIGRAM In 1 GRAM / BENZOYL PEROXIDE 25 MILLIGRAM In 1 GRAM TOPICAL GEL [EPIDUO], Adapalene/Benzoyl Peroxide 0.1%-2.5% Topical application Gel/Jelly [EPIDUO], Epiduo Pump, 0.1%-2.5% topical gel, ADAPALENE 1 mg in 1 g / BENZOYL PEROXIDE 25 mg in 1 g TOPICAL GEL [Epiduo], Epiduo Pump 0.1%-2.5% Topical Gel
Sources
Derived from the NIH UMLS (Unified Medical Language System)


You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree