Cardiovascular Medicine Book

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Metoprolol

Aka: Metoprolol, Lopressor, Metoprolol Succinate, Metoprolol Tartrate, Toprol XL
  1. See Also
    1. Beta Blocker
  2. Mechanism
    1. Selective Beta Blocker
  3. Indications
    1. Myocardial Infarction
    2. Atrial Fibrillation Rate Control
  4. Pharmacokinetics
    1. Intravenous dosing
      1. Onset of action in 5 minutes after intravenous dose
      2. Sustained response for 6-8 hours
  5. Dosing
    1. Oral: Metoprolol Succinate (Toprol XL, extended release)
      1. Preferred oral formulation
      2. Dose: 50-100 mg orally daily (Maximum 400 mg/day)
    2. Oral: Metoprolol Tartrate (Lopressor, immediate release)
      1. Dose: 50 mg orally twice daily (Maximum 450 mg/day)
    3. Intravenous Metoprolol (Lopressor)
      1. Load: 2.5 to 5 mg IV over 2 to 5 minutes
      2. Repeated up to 3 doses (15 mg maximum)
Medication Costs
Metoprolol Tartrate (on 6/18/2017 at Walmart.com)
Metoprolol Tartrate 100mg #60 tablets for $4.00 $0.07 each
Metoprolol Tartrate 100mg #180 tablets for $10.00 $0.06 each
Metoprolol Tartrate 25mg #60 tablets for $4.00 $0.07 each
Metoprolol Tartrate 25mg #180 tablets for $10.00 $0.06 each
Metoprolol Tartrate 50mg #60 tablets for $4.00 $0.07 each
Metoprolol Tartrate 50mg #180 tablets for $10.00 $0.06 each
metoprolol (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
METOPROLOL SUCC ER 100 MG TAB Generic $0.39 each
METOPROLOL SUCC ER 200 MG TAB Generic $0.75 each
METOPROLOL SUCC ER 25 MG TAB Generic $0.22 each
METOPROLOL SUCC ER 50 MG TAB Generic $0.23 each
METOPROLOL TARTRATE 100 MG TAB Generic $0.04 each
METOPROLOL TARTRATE 25 MG TAB Generic $0.02 each
METOPROLOL TARTRATE 50 MG TAB Generic $0.02 each
METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB Generic $1.04 each
METOPROLOL-HYDROCHLOROTHIAZIDE 50-25 MG TAB Generic $0.81 each
toprol xl (on 1/18/2017 at Medicaid.Gov Pharmacy Drug pricing)
TOPROL XL 100 MG TABLET Generic $0.39 each
TOPROL XL 25 MG TABLET Generic $0.22 each
TOPROL XL 50 MG TABLET Generic $0.23 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Metoprolol (C0025859)

Definition (MSH) A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Definition (NCI) A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008790
SnomedCT 372826007, 7092007
LNC LP16204-7, MTHU016612
English Metoprolol, 2-Propanol, 1-(4-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, metoprolol (medication), Metoprolol [Chemical/Ingredient], METOPROLOL, metoprolol, Metoprolol (product), Metoprolol (substance)
Swedish Metoprolol
Czech metoprolol
Finnish Metoprololi
Russian N 93-26, METOPROLOL, МЕТОПРОЛОЛ, Н 93-26
Japanese 酒石酸メトプロロール, セレクナート, メデピン, メルコモン, ロプレソール, セロケン, ロプレソールSR, シオプトロール, セグミューラー, ココナリン, シプセロン, モジュメニー, セロケンL, メトプリック, メトラスター, カルスホン, メトプロロール
Polish Metoprolol
Spanish metoprolol (producto), metoprolol (sustancia), metoprolol, Metoprolol
French Métoprolol
German Metoprolol
Italian Metoprololo
Portuguese Metoprolol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Metoprolol Tartrate (C0700548)

Definition (NCI) The tartrate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol tartrate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008790
SnomedCT 318463000, 72770009
English Tartrate, Metoprolol, metoprolol tartrate, metoprolol tartrate (medication), METOPROLOL TARTRATE, Metoprolol Tartrate [Chemical/Ingredient], Metoprolol tartrate, Metoprolol tartrate (substance), Metoprolol tartrate [dup] (substance), Metoprolol Tartrate
French Tartrate de métoprolol, Métoprolol tartrate
Spanish tartrato de metoprolol (sustancia), tartrato de metoprolol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Lopressor (C0700776)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008790
English Lopresor, Novartis Brand of Metprolol Tartrate, lopresor, lopressor, Lopressor
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Toprol-XL (C0723783)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C402833
English Toprol-XL, toprol-xl, toprol xl, Toprol XL
Sources
Derived from the NIH UMLS (Unified Medical Language System)


metoprolol succinate (C0724633)

Definition (NCI) The succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol succinate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C402833
SnomedCT 412432007
English metoprolol succinate (medication), metoprolol succinate, METOPROLOL SUCCINATE, metoprolol succinate [Chemical/Ingredient], succinate metoprolol, metoprolol CR-XL, Metoprolol succinate (substance), Metoprolol succinate, Metoprolol Succinate
Spanish succinato de metoprolol (sustancia), succinato de metoprolol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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