I. Indications

  1. Effective alternative to Penicillins
  2. Covers Gram Positive Cocci
  3. Clinical Conditions
    1. Skin and Soft Tissue Infection
    2. Streptococcal Pharyngitis
    3. Not indicated for Otitis Media

III. Preparations: Oral

  1. Directions
    1. May take with or without food
  2. Cephalexin (Keflex)
    1. Adult: 250 to 500 mg PO qid
    2. Child
      1. Otitis Media: 75 to 100 mg/kg/day divided qid
      2. Standard Dose: 25 to 50 mg/kg/day divided qid
  3. Cefadroxil (Duricef)
    1. Adult: 1 to 2 grams/day divided qd to bid
    2. Child: 30 mg/kg/day divided bid

IV. Parenteral: Cefazolin (Ancef)

  1. Adult: 0.5 to 1.5 grams IM or IV every 6-8 hours
  2. Child
    1. Standard: 25 to 50 mg/kg/day divided q6-8 hours
    2. Severe Infection: 100 mg/kg/day divided q6-8 hours
    3. Maximum: 2 grams per dose

Images: Related links to external sites (from Google)

Cost: Medications

CEPHALEXIN (on 2/10/2012 at Target.com)
CEPHALEXIN 250 MG Capsule #30 for $4.00 ($0.13/unit)
CEPHALEXIN 500 MG Capsule #30 for $4.00 ($0.13/unit)
Cephalexin (on 2/9/2012 at DrugStore.com)
Cephalexin 125mg/5ml Suspension 100ml Bottle #1 for $15.99 ($15.99/unit)
Cephalexin 250mg/5ml Suspension 100ml Bottle #1 for $26.99 ($26.99/unit)
Cephalexin 500mg Capsules #30 for $16.99 ($0.57/unit)
Cephalexin 250mg Capsules #30 for $14.99 ($0.50/unit)
Cephalexin 250mg/5ml Suspension 200ml Bottle #1 for $22.99 ($22.99/unit)
Keflex (on 2/9/2012 at DrugStore.com)
Keflex 500mg Capsules #30 for $175.99 ($5.87/unit)
Keflex 750mg Capsules #50 for $215.98 ($4.32/unit)

Ontology: Cefadroxil (C0007538)

Definition (MSH) Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.
Definition (NCI) A semi-synthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cefadroxil binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002434
SnomedCT 13414000, 372651006
English 4 Hydroxycephalexin, 4-Hydroxycephalexin, Cefadroxil, Cephadroxyl, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-, (6R,7R)-7-(((2R)-Amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, cefadroxil, CEFADROXIL, Cefadroxil [Chemical/Ingredient], cephadroxyl, Cefadroxil (product), Cefadroxil (substance)
Swedish Cefadroxil
Czech cefadroxil
Finnish Kefadroksiili
Italian 4-Idrossi cefalessina, Cefadrossil
Russian TSEFADROKSIL, ЦЕФАДРОКСИЛ
Japanese セファドロキシル
Polish Cefadroksyl
Spanish cefadroxilo (producto), cefadroxilo (sustancia), cefadroxilo, Cefadroxilo
French Céfadroxil
German Cefadroxil
Portuguese Cefadroxila

Ontology: Cefazolin (C0007546)

Definition (MSH) A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Definition (NCI) A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002437
SnomedCT 323932006, 81088002, 387470007
English Cefazolin, Cephazolin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-, (6R-trans)-, cefazolin, (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Cefazolin [Chemical/Ingredient], cephazolin, ceFAZolin, Cephazolin (product), Cephazolin (substance), CEFAZOLIN
Swedish Cefazolin
Czech cefazolin
Spanish Cephazolin, cefazolina (producto), cefazolina (sustancia), cefazolina, Cefazolina
Finnish Kefatsoliini
Russian TSEFAZOLIN, ЦЕФАЗОЛИН
Japanese セファゾリン, セファゾリンナトリウム
Polish Cefazolina
French Céfazoline
German Cefazolin, Cephazolin
Italian Cefazolina
Portuguese Cefazolina

Ontology: Cephalexin (C0007716)

Definition (CHV) an antibiotic drug
Definition (CHV) an antibiotic drug
Definition (MSH) A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.
Definition (NCI) A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms.
Definition (NCI) An antibiotic drug that belongs to the family of drugs called cephalosporins.
Definition (PDQ) A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43417&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43417&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C356" NCI Thesaurus)
Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002506
SnomedCT 54887004, 387304003
English Cefalexin, Cephalexin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-, cephalexin, cephalexin (medication), CEPHALEXIN, Cephalexin [Chemical/Ingredient], cefalexin, Cephalexin (product), Cephalexin (substance)
Swedish Cefalexin
Czech cefalexin
Finnish Kefaleksiini
German Cefalexin, Cephalexin
Russian TSEFALEKSIN, ЦЕФАЛЕКСИН
Japanese セファレキシン
Croatian CEFALEKSIN
Polish Cefaleksyna
Spanish cefalexina (producto), cefalexina (sustancia), cefalexina, Cefalexina
French Céfalexine
Italian Cefalexina
Portuguese Cefalexina

Ontology: Keflex (C0700517)

Concepts Organic Chemical (T109) , Antibiotic(T195)
English Keflex, keflex

Ontology: Ancef (C0700926)

Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002437
English ancef, Ancef

Ontology: Duricef (C0701890)

Concepts Organic Chemical (T109) , Antibiotic(T195)
MSH D002434
English duricef, Duricef