II. Pharmacology

  1. Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
  2. Sulfonamide Allergy does not cross react with sulfur, sulfate, Sulfites

III. Preparations: Sulfonylarylamines (Sulfa agents)

  1. General
    1. Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
  2. Sulfa Antibiotics
    1. Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
    2. Sulfadiazine
    3. Sulfacetamide
  3. Sulfa Antiinflammatories
    1. Sulfasalazine
  4. Protease Inhibitors (HIV Infection)
    1. Darunavir (Prezista)
    2. Fosamprenavir (Lexiva)

IV. Preparations: Non-Sulfonylarylamines

  1. General
    1. Similar structure to Sulfonylarylamines , but hypersensitivity cross-reactivity is uncommon
    2. However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
  2. Diuretics
    1. All Thiazide Diuretics
    2. Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
  3. Anti-hyperglycemics (Diabetes Mellitus)
    1. Sulfonylureas (e.g. Glipizide)
  4. Analgesics
    1. Celecoxib (Celebrex)

V. Preparations: Sulfonamide Moieties

  1. General
    1. Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
    2. However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
  2. Neurologic agents
    1. Sumatriptan (Imitrex)
    2. Topiramate (Topamax)
    3. Zonisamide (Zonagran)
  3. Protease Inhibitor (Hepatitis C Infection)
    1. Simeprevir (Olysio)

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Ontology: Allergy to sulfonamides (C0038757)

Concepts Disease or Syndrome (T047)
SnomedCT 91939003
English SULFA ALLERGY, allergy sulfas, allergy to sulfa drugs, allergies drugs sulpha, allergies drug sulfa, allergy sulfa, sulfa drugs allergy, allergies sulfonamide, sulfa allergy, allergies sulfa, sulfonamide allergy, allergy drug sulfa, allergy drug sulpha, Sulfonamide allergy, Sulphonamide allergy, Allergy to sulfa drugs, Allergy to sulfonamides, Allergy to sulfonamides (disorder), Allergy to sulpha drugs, Allergy to sulphonamides
Dutch allergie voor sulfonamide
French Allergie aux sulfonamides
German Sulfonamidallergie
Italian Allergia alla sulfonamide
Portuguese Alergia a sulfonamida
Spanish Alergia a sulfonamidas, alergia a las sulfamidas, alergia a las sulfonamidas (trastorno), alergia a las sulfonamidas
Japanese スルホンアミドアレルギー, スルホンアミドアレルギー
Czech Alergie na sulfonamidy
Hungarian Szulfonamid allergia