II. Normal

  1. Range: 50-350 mg/dl
  2. Varies by age

III. Increased IgA

  1. Lymphoproliferative disorders (e.g. Multiple Myeloma)
  2. Berger's Disease (IgA nephropathy)
  3. Chronic infection
  4. Autoimmune disorders
  5. Liver disease (e.g. Portal Cirrhosis)
  6. Henoch Schonlein Purpura

IV. Decreased IgA

  1. IgA Hypogammaglobulinemia
  2. Protein losing Enteropathy
  3. Hereditary Ataxia and telangiectasia
  4. Nephrotic Syndrome

V. References

  1. Bakerman (1984) ABCs of Lab Data, p. 252-3

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Ontology: Immunoglobulin A (C0020835)

Definition (MSH) Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Definition (CSP) predominant immunoglobulin in seromucous secretions such as saliva, colostrum, milk, tracheobronchial and genitourinary secretions.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D007070
SnomedCT 143330004, 165942009, 46046006
LNC LP14669-3, MTHU005223
English IgA, Immunoglobulin A, Immunoglobulin A [Chemical/Ingredient], immunoglobulin a, immunoglobulin a (IgA), immu globulin,alpha (IgA), Immunoglobulin A (procedure), Immunoglobulin A (substance), Immunoglobulin IgA, Immunoglobulin IgA (substance), immunoglobulin A, IgA - Immunoglobulin A, Immunoglobulin IgA, NOS
Swedish Immunglobulin A
Czech imunoglobulin A, IgA
Finnish Immunoglobuliini A
Russian IMMUNOGLOBULIN A, IGA, ИММУНОГЛОБУЛИН A
Italian IgA, Immunoglobulina A
Croatian IMUNOGLOBULIN A, IgA
Polish Immunoglobulina A
Spanish Inmunoglobulinas A, inmunoglobulina IgA (sustancia), inmunoglobulina IgA, inmunoglobulina A (sustancia), inmunoglobulina A, IgA, Inmunoglobulina A
Portuguese Imunoglobulinas A, IgA, Imunoglobulina A
French IgA, Immunoglobuline A
German IgA, Immunglobulin A