II. Indications

  1. Suspected Mononucleosis with negative heterophile tests
  2. Mononucleosis-Like Syndrome

III. Physiology

  1. IgM Viral Capsid Antigen (xIgM VCA or EBV IgM)
    1. Present at onset of symptoms
    2. Persist for 4-8 weeks after onset
  2. IgG Viral Capsid Antigen (xIgG VCA or EBV IgG)
    1. Present early in symptom course
    2. Persist life long
  3. Epstein-Barr Virus Nuclear Antibody (xEBNA)
    1. Suggests past infection
    2. Not present until 6-8 weeks after symptom onset

IV. Interpretation

  1. Acute phase antibodies: xEA, xIgM VCA
  2. Convalescent Antibody: xIgG VCA
  3. Recovered State: xIgG VCA, xEBNA

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Ontology: Antibody test; Epstein-Barr (EB) virus, nuclear antigen (EBNA) (C0373901)

Definition (NCI_CDISC) A measurement of the Epstein-Barr nuclear antigen in a biological specimen.
Definition (NCI) The determination of the amount of Epstein-Barr nuclear antigen present in a sample.
Concepts Laboratory Procedure (T059)
CPT 86664
English Antibody test; Epstein-Barr (EB) virus, nuclear antigen (EBNA), Antibody; Epstein-Barr (EB) virus, nuclear antigen (EBNA), ANTIBODY EPSTEIN-BARR EB VIRUS NUCLEAR AG EBNA, Epstein-Barr Nuclear Antigen Measurement, Epstein-Barr (EB) virus nuclear antigen (EBNA) antibody titer, EPSTEIN-BARR NUCLEAR ANTIGEN, Epstein-barr nuclear antigen, Epstein-Barr Nuclear Antigen, EBNAG

Ontology: Antibody test; Epstein-Barr (EB) virus, viral capsid (VCA) (C0373902)

Concepts Laboratory Procedure (T059)
CPT 86665
English Antibody test; Epstein-Barr (EB) virus, viral capsid (VCA), Antibody; Epstein-Barr (EB) virus, viral capsid (VCA), ANTIBODY EPSTEIN-BARR EB VIRUS VIRAL CAPSID VCA, EPSTEIN-BARR CAPSID VCA, Epstein-Barr (EB) virus viral capsid (VCA) antibody titer, Epstein-barr capsid vca

Ontology: Epstein-Barr virus capsid antibody (C0443705)

Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
SnomedCT 116869000
LNC LP38068-0, MTHU025100
English Epstein-Barr virus capsid ab, Epstein Barr virus capsid Antibody, Epstein Barr virus capsid Ab, Epstein-Barr virus capsid antibody, Epstein-Barr virus capsid antibody (substance)
Spanish anticuerpo anti - cápside del EBV, anticuerpo anti - cápside del VEB, anticuerpo anti - cápside del virus del Epstein Barr (sustancia), anticuerpo anti - cápside del virus del Epstein Barr

Ontology: Epstein Barr virus capsid Ab.IgG (C0806040)

Concepts Immunologic Factor (T129)
LNC LP38070-6, MTHU024968
English Epstein Barr virus capsid Antibody.immunoglobulin G, Epstein Barr virus capsid Ab.IgG

Ontology: Epstein Barr virus capsid Ab.IgM (C0806041)

Concepts Immunologic Factor (T129)
LNC LP38071-4, MTHU024970
English Epstein Barr virus capsid Antibody.immunoglobulin M, Epstein Barr virus capsid Ab.IgM